Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
Mol Ecol. 2023 Jan;32(1):45-60. doi: 10.1111/mec.16739. Epub 2022 Nov 2.
The ability to transition between different behavioural stages is a widespread phenomenon across the animal kingdom. Such behavioural adaptations are often linked to changes in the sensitivity of those neurons that sense chemical cues associated with the respective behaviours. To identify the genetic mechanisms that regulate neuronal sensitivity, and by that behaviour, typically *omics approaches, such as RNA- and protein-sequencing, are applied to sensory organs of individuals displaying differences in behaviour. In this review, we discuss these genetic mechanisms and how they impact neuronal sensitivity, summarize the correlative and functional evidence for their role in regulating behaviour and discuss future directions. As such, this review can help interpret *omics data by providing a comprehensive list of already identified genes and mechanisms that impact behaviour through changes in neuronal sensitivity.
不同行为阶段之间转换的能力是动物界普遍存在的现象。这种行为适应通常与那些感知与各自行为相关的化学线索的神经元的敏感性变化有关。为了确定调节神经元敏感性的遗传机制,并通过这种行为,通常会应用 RNA 和蛋白质测序等“组学”方法,对表现出行为差异的个体的感觉器官进行研究。在这篇综述中,我们讨论了这些遗传机制以及它们如何影响神经元的敏感性,总结了它们在调节行为中的作用的相关和功能证据,并讨论了未来的方向。因此,通过提供一份全面的已确定基因和机制的清单,这些基因和机制通过改变神经元的敏感性来影响行为,本综述可以帮助解释“组学”数据。