Godoy Ricardo, Machuca Juan, Venthur Herbert, Quiroz Andrés, Mutis Ana
Programa de Doctorado en Ciencias de Recursos Naturales, Universidad de La Frontera, Temuco, Chile.
Centro de Investigación Biotecnológica Aplicada al Medio Ambiente (CIBAMA), Universidad de La Frontera, Temuco, Chile.
Front Physiol. 2021 Mar 31;12:643281. doi: 10.3389/fphys.2021.643281. eCollection 2021.
Lepidoptera are used as a model for the study of insect olfactory proteins. Among them, odorant degrading enzymes (ODEs), that degrade odorant molecules to maintain the sensitivity of antennae, have received less attention. In particular, antennal esterases (AEs; responsible for ester degradation) are crucial for intraspecific communication in Lepidoptera. Currently, transcriptomic and genomic studies have provided AEs in several species. However, efforts in gene annotation, classification, and functional assignment are still lacking. Therefore, we propose to combine evidence at evolutionary, structural, and functional level to update ODEs as well as key information into an easier classification, particularly of AEs. Finally, the kinetic parameters for putative inhibition of ODEs are discussed in terms of its role in future integrated pest management (IPM) strategies.
鳞翅目昆虫被用作研究昆虫嗅觉蛋白的模型。其中，负责降解气味分子以维持触角敏感性的气味降解酶（ODEs）受到的关注较少。特别是触角酯酶（AEs；负责酯类降解）对鳞翅目昆虫的种内通讯至关重要。目前，转录组学和基因组学研究已经在多个物种中鉴定出了AEs。然而，在基因注释、分类和功能分配方面仍存在不足。因此，我们建议结合进化、结构和功能层面的证据，将ODEs以及关键信息更新为更易于分类的形式，特别是针对AEs。最后，从其在未来害虫综合治理（IPM）策略中的作用角度讨论了假定的ODEs抑制动力学参数。
