Ophthalmic Surg Lasers Imaging Retina. 2022 Oct;53(10):529-536. doi: 10.3928/23258160-20220919-01. Epub 2022 Oct 1.
To determine if age-related macular degeneration (AMD) status affects longitudinal retinal vessel changes.
Retrospective, cohort study of 125 eyes (75 patients) with AMD, following retinal vessel density (VD) and foveal avascular zone (FAZ) measurements using optical coherence tomography angiography (OCT-A) over 24 months.
FAZ area ( < .001) and perimeter ( < .001) increased over 2 years, with no difference between nonexudative and exudative AMD ( = .134-.976). Eyes with geographic atrophy (GA) showed greater progressive VD loss ( = .023-.038), and greater increase in FAZ area ( = .044) and perimeter ( = .040) compared to eyes without GA. Neither baseline nor 2-year change in vascular parameters were associated with choroidal neovascularization (CNV) or GA incidence in nonexudative AMD, or anti-VEGF injection frequency in exudative AMD ( = .070-.952).
AMD eyes with GA undergo more rapid loss of retinal vessel density and FAZ enlargement over 2 years, suggesting a relationship between the retinal vasculature and AMD pathophysiology. .
确定年龄相关性黄斑变性（AMD）的状态是否会影响视网膜血管的纵向变化。
回顾性队列研究纳入了 75 例 125 只 AMD 眼，通过光学相干断层扫描血管造影（OCT-A）对其视网膜血管密度（VD）和中心凹无血管区（FAZ）进行了 24 个月的随访。
2 年内 FAZ 面积（<.001）和周长（<.001）增大，渗出性与非渗出性 AMD 之间无差异（=.134-.976）。与无 GA 的眼相比，伴有地图状萎缩（GA）的眼表现出更显著的 VD 进行性丧失（=.023-.038），以及 FAZ 面积（=.044）和周长（=.040）的更大增加。血管参数的基线值和 2 年变化均与非渗出性 AMD 的脉络膜新生血管（CNV）或 GA 发生率，以及渗出性 AMD 的抗 VEGF 注射频率无关（=.070-.952）。
2 年内，伴有 GA 的 AMD 眼的视网膜血管密度丧失和 FAZ 增大更快，提示视网膜血管与 AMD 病理生理学之间存在关联。
