一项随机对照试验评估药物管理审查服务对改善叙利亚难民药物知识和用药依从性的效果。

Improving Syrian refugees' knowledge of medications and adherence following a randomized control trial assessing the effect of a medication management review service.

机构信息

Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, Qatar.

Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan.

出版信息

PLoS One. 2022 Oct 14;17(10):e0276304. doi: 10.1371/journal.pone.0276304. eCollection 2022.

DOI:10.1371/journal.pone.0276304

PMID:36240214

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9565448/

Abstract

BACKGROUND

Syrian refugees living in Jordan have many chronic conditions and use many medications. Pharmacists delivering the Medication Management Review (MMR) service can have a role in improving this growing global refugees' problem.

OBJECTIVES

To assess the effect of the MMR service on adherence to treatment therapy and knowledge of chronic medications for Syrian refugees residing in Jordan.

METHODS

This randomized intervention control single-blinded study was conducted in Jordan. Syrian refugees were recruited and randomized into intervention and control groups. Two home visits were delivered to each participant, at baseline and three months later. All participants completed questionnaires regarding adherence and knowledge. As a part of the MMR service, treatment-related problems (TRPs) were recognized for all patients; recommendations to resolve these TRPs were only delivered to intervention group refugees' physicians; TRPs were corrected. At follow-up, TRPs assessment, adherence and medication knowledge were assessed for all refugee participants.

RESULTS

Participants (n = 106; intervention n = 53, control n = 53) had a number of medications and diagnosed chronic diseases of 5.8 ± 2.1 and 2.97 ± 1.16 per participant respectively. A significant improvement in the adherence and knowledge scores were noted in the intervention (P < 0.001 for both) but not the control group (P = 0.229, P = 0.07 respectively).

CONCLUSION

The MMR service can significantly improve refugees' TRPs, adherence to therapy and knowledge of chronic medications. If this approach was extended to the large scale, many refugees in need would be able to access a quality essential health-care service; a step towards achieving universal health coverage.

TRIAL REGISTRATION

Registry: ClinicalTrials.gov Identifier: NCT04554810.

摘要

背景

居住在约旦的叙利亚难民患有许多慢性疾病，并使用许多药物。提供药物管理审查（MMR）服务的药剂师可以在改善这一日益严重的全球难民问题方面发挥作用。

目的

评估 MMR 服务对居住在约旦的叙利亚难民的治疗依从性和慢性药物知识的影响。

方法

这是一项在约旦进行的随机干预对照单盲研究。招募了叙利亚难民，并将他们随机分为干预组和对照组。每个参与者都进行了两次家访，一次在基线时，一次在三个月后。所有参与者都完成了关于依从性和知识的问卷。作为 MMR 服务的一部分，对所有患者的治疗相关问题（TRP）进行了识别；仅向干预组难民的医生提供了解决这些 TRP 的建议；TRP 得到了纠正。在随访时，对所有难民参与者进行了 TRP 评估、依从性和药物知识评估。