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患者因素与药物依从性之间的关联:约旦的经验。

Associations between patient factors and medication adherence: A Jordanian experience.

作者信息

Basheti Iman A, Hait Sami Saqf El, Qunaibi Eyad A, Aburuz Salah, Bulatova Nailya

机构信息

Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Sciences University , Amman ( Jordan ).

Department of Quality Assurance, Sanofi, Jeddah, ( Saudi Arabia ).

出版信息

Pharm Pract (Granada). 2016 Jan-Mar;14(1):639. doi: 10.18549/PharmPract.2016.01.639. Epub 2016 Mar 15.

Abstract

OBJECTIVE

To explore the effect of patient characteristics and health beliefs on their medication adherence.

METHODS

Patients (n=167) with chronic conditions (mean age 58.9; SD=13.54, 53% males) were recruited from March 2009- to March 2010 using a cross sectional study design. Data collected included patients' demographics, medical conditions, medications therapeutic regimen, frequency of physician visits and health beliefs. Patient self-reported adherence to medications was assessed by the researcher using a validated and published scale. Treatment related problems (TRPs) were evaluated for each patient by competent clinical pharmacists. Associations between patient characteristics/health beliefs with adherence were explored.

RESULTS

About half of the patients (46.1%) were non-adherent. A significant association was found between lower adherence and higher number of disease states (p<0.001), higher number of medications (p=0.001), and higher number of identified TRPs (p = 0.003). Patient adherence was positively affected by older age, higher educational level, and higher number of physician visits per month, while it was negatively affected by reporting difficulties with getting prescription refills on time.

CONCLUSION

This study identified different factors that may negatively affect adherence, including higher number of medications and disease states, higher number of identified TRPs and inability to getting prescription refills on time. Hence, more care needs to be provided to patients with complex therapeutic regimens in order to enhance adherence.

摘要

目的

探讨患者特征和健康观念对其用药依从性的影响。

方法

采用横断面研究设计,于2009年3月至2010年3月招募了患有慢性疾病的患者(n = 167)(平均年龄58.9岁;标准差= 13.54,男性占53%)。收集的数据包括患者的人口统计学信息、医疗状况、药物治疗方案、就诊频率和健康观念。研究人员使用经过验证并已发表的量表评估患者自我报告的用药依从性。由专业临床药剂师对每位患者的治疗相关问题(TRP)进行评估。探讨患者特征/健康观念与依从性之间的关联。

结果

约一半的患者(46.1%)不依从。发现依从性较低与疾病状态数量较多(p < 0.001)、药物数量较多(p = 0.001)以及已识别的TRP数量较多(p = 0.003)之间存在显著关联。患者的依从性受到年龄较大、教育水平较高以及每月就诊次数较多的积极影响,而受到按时获取处方续填困难报告的消极影响。

结论

本研究确定了可能对依从性产生负面影响的不同因素,包括药物和疾病状态数量较多、已识别的TRP数量较多以及无法按时获取处方续填。因此,需要为治疗方案复杂的患者提供更多护理,以提高依从性。

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