Immunology Service and Uveitis Unit, University Hospital of León, León, Spain.
Instituto de Biomedicina (IBIOMED), University of León, León, Spain.
Ocul Immunol Inflamm. 2024 Feb;32(2):141-147. doi: 10.1080/09273948.2022.2129693. Epub 2022 Oct 14.
To measure, characterize, and evaluate the clinical significance of anti-retinal antibodies in patients with sarcoid uveitis.
SUBJECTS/METHODS: Prospective study of anti-retinal antibodies in 45 patients with biopsy-proven sarcoidosis (25 with and 20 without uveitis). Results were compared with patients with confirmed infectious uveitis (n = 40) and non-infectious uveitis (n = 40).
Among sarcoidosis patients, anti-retinal antibodies were positive in 23/25 patients with uveitis and in 15/20 without uveitis [ = ns]. The most common antigens recognized were carbonic anhydrase II (14/23) and α-enolase (6/23). Anti-carbonic anhydrase II autoantibodies were infrequently detected in sarcoidosis patients without uveitis (2 out 15, < .001), in patients with infectious uveitis (1 out 18, < .001), and in patients with non-infectious uveitis (8 out 37, < .001).
Anti-retinal antibodies recognizing carbonic anhydrase II are common in sarcoid uveitis. Although not fully sensitive and specific, they might be a useful non-invasive diagnostic tool for the diagnosis of sarcoid uveitis.
测量、描述和评估患有结节病性葡萄膜炎患者的抗视网膜抗体的临床意义。
对象/方法：对 45 例经活检证实的结节病患者（25 例伴葡萄膜炎，20 例不伴葡萄膜炎）进行抗视网膜抗体的前瞻性研究。结果与确诊的感染性葡萄膜炎患者（n=40）和非感染性葡萄膜炎患者（n=40）进行比较。
在结节病患者中，25 例葡萄膜炎患者中有 23 例和 20 例无葡萄膜炎患者中 15 例抗视网膜抗体阳性[=无统计学差异]。最常见的识别抗原是碳酸酐酶 II（14/23）和α-烯醇酶（6/23）。在无葡萄膜炎的结节病患者中（15 例中 2 例，<.001）、感染性葡萄膜炎患者中（18 例中 1 例，<.001）和非感染性葡萄膜炎患者中（37 例中 8 例，<.001），很少检测到抗碳酸酐酶 II 自身抗体。
识别碳酸酐酶 II 的抗视网膜抗体在结节病性葡萄膜炎中很常见。尽管不完全敏感和特异，但它们可能是一种有用的非侵入性诊断工具，用于诊断结节病性葡萄膜炎。
