结节病中的抗视网膜抗体。
Anti-retinal Antibodies in Sarcoidosis.
机构信息
Immunology Service and Uveitis Unit, University Hospital of León, León, Spain.
Instituto de Biomedicina (IBIOMED), University of León, León, Spain.
出版信息
Ocul Immunol Inflamm. 2024 Feb;32(2):141-147. doi: 10.1080/09273948.2022.2129693. Epub 2022 Oct 14.
PURPOSE
To measure, characterize, and evaluate the clinical significance of anti-retinal antibodies in patients with sarcoid uveitis.
SUBJECTS/METHODS: Prospective study of anti-retinal antibodies in 45 patients with biopsy-proven sarcoidosis (25 with and 20 without uveitis). Results were compared with patients with confirmed infectious uveitis (n = 40) and non-infectious uveitis (n = 40).
RESULTS
Among sarcoidosis patients, anti-retinal antibodies were positive in 23/25 patients with uveitis and in 15/20 without uveitis [ = ns]. The most common antigens recognized were carbonic anhydrase II (14/23) and α-enolase (6/23). Anti-carbonic anhydrase II autoantibodies were infrequently detected in sarcoidosis patients without uveitis (2 out 15, < .001), in patients with infectious uveitis (1 out 18, < .001), and in patients with non-infectious uveitis (8 out 37, < .001).
CONCLUSIONS
Anti-retinal antibodies recognizing carbonic anhydrase II are common in sarcoid uveitis. Although not fully sensitive and specific, they might be a useful non-invasive diagnostic tool for the diagnosis of sarcoid uveitis.
目的
测量、描述和评估患有结节病性葡萄膜炎患者的抗视网膜抗体的临床意义。
对象/方法：对 45 例经活检证实的结节病患者（25 例伴葡萄膜炎，20 例不伴葡萄膜炎）进行抗视网膜抗体的前瞻性研究。结果与确诊的感染性葡萄膜炎患者（n=40）和非感染性葡萄膜炎患者（n=40）进行比较。
结果
在结节病患者中，25 例葡萄膜炎患者中有 23 例和 20 例无葡萄膜炎患者中 15 例抗视网膜抗体阳性[=无统计学差异]。最常见的识别抗原是碳酸酐酶 II（14/23）和α-烯醇酶（6/23）。在无葡萄膜炎的结节病患者中（15 例中 2 例，<.001）、感染性葡萄膜炎患者中（18 例中 1 例，<.001）和非感染性葡萄膜炎患者中（37 例中 8 例，<.001），很少检测到抗碳酸酐酶 II 自身抗体。
结论
识别碳酸酐酶 II 的抗视网膜抗体在结节病性葡萄膜炎中很常见。尽管不完全敏感和特异，但它们可能是一种有用的非侵入性诊断工具，用于诊断结节病性葡萄膜炎。
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