Cancer Molecular Target Herbal Research Laboratory, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration (RDA), Eumseong, Republic of Korea.
Antioxid Redox Signal. 2023 Jun;38(16-18):1101-1121. doi: 10.1089/ars.2022.0144. Epub 2023 Mar 8.
Drug-induced liver injury (DILI) or hepatotoxicity has been a hot issue to overcome on the safety and physiological function of the liver, since it is known to have biochemical, cellular, immunological, and molecular alterations in the liver mainly induced by alcohol, chemicals, drugs, heavy metals, and genetic factors. Recently efficient therapeutic and preventive strategies by some phytochemicals are of interest, targeting oxidative stress-mediated hepatotoxicity alone or in combination with anticancer drugs. To assess DILI, the variety of and animal models has been developed mainly by using carbon tetrachloride, d-galactosamine, acetaminophen, and lipopolysaccharide. Also, the mechanisms on hepatotoxicity by several drugs and herbs have been explored in detail. Recent studies reveal that antioxidants including vitamins and some phytochemicals were reported to prevent against DILI. Antioxidant therapy with some phytochemicals is noteworthy, since oxidative stress is critically involved in DILI production of chemically reactive oxygen species or metabolites, impairment of mitochondrial respiratory chain, and induction of redox cycling. For efficient antioxidant therapy, DILI susceptibility, Human Leukocyte Antigen genetic factors, biomarkers, and pathogenesis implicated in hepatotoxicity should be further explored in association with oxidative stress-mediated signaling, while more randomized preclinical and clinical trials are required with optimal safe doses of drugs and/or phytochemicals alone or in combination for efficient clinical practice along with the development of advanced DILI diagnostic tools. 38, 1101-1121.
药物性肝损伤（DILI）或肝毒性一直是一个热门话题，需要克服肝脏的安全性和生理功能，因为已知它主要由酒精、化学物质、药物、重金属和遗传因素引起的肝生化、细胞、免疫和分子改变。最近，一些植物化学物质的有效治疗和预防策略引起了人们的兴趣，针对氧化应激介导的肝毒性，单独或与抗癌药物联合使用。为了评估 DILI，已经开发了多种动物模型，主要使用四氯化碳、半乳糖胺、对乙酰氨基酚和脂多糖。此外，还详细探讨了几种药物和草药引起肝毒性的机制。最近的研究表明，抗氧化剂包括维生素和一些植物化学物质被报道可以预防 DILI。用一些植物化学物质进行抗氧化治疗值得注意，因为氧化应激在 DILI 中起关键作用，产生化学活性氧或代谢物、损害线粒体呼吸链和诱导氧化还原循环。为了进行有效的抗氧化治疗，需要进一步探讨与氧化应激介导的信号转导相关的 DILI 易感性、人类白细胞抗原遗传因素、生物标志物和发病机制，同时需要更多的随机临床前和临床试验，以确定药物和/或植物化学物质的最佳安全剂量，单独或联合使用，以实现有效的临床实践，并开发先进的 DILI 诊断工具。38, 1101-1121.
