Eugenio-Pérez Dianelena, Montes de Oca-Solano Héctor Adolfo, Pedraza-Chaverri José
a Department of Biology, Faculty of Chemistry , National Autonomous University of Mexico (UNAM) , University City , Mexico City , DF , Mexico.
Pharm Biol. 2016 Oct;54(10):2340-52. doi: 10.3109/13880209.2016.1150302. Epub 2016 Mar 9.
Context Acetaminophen (APAP), also known as paracetamol and N-acetyl p-aminophenol, is one of the most frequently used drugs for analgesic and antipyretic purposes on a worldwide basis. It is safe and effective at recommended doses but has the potential for causing hepatotoxicity and acute liver failure (ALF) with overdose. To solve this problem, different strategies have been developed, including the use of compounds isolated from food, which have been studied to characterize their efficacy as natural dietary antioxidants. Objective The objective of this study is to show the beneficial effects of a variety of natural compounds and their use against acetaminophen-induced hepatotoxicity. Methods PubMed database was reviewed to compile data about natural compounds with hepatoprotective effects against APAP toxicity. Results and conclusion As a result, the health-promoting properties of 13 different food-derived compounds with protective effect against APAP-induced hepatotoxicity were described as well as the mechanisms involved in hepatoprotection.
对乙酰氨基酚（APAP），也被称为扑热息痛和N-乙酰对氨基酚，是全球范围内最常用于止痛和解热目的的药物之一。在推荐剂量下它安全有效，但过量服用有导致肝毒性和急性肝衰竭（ALF）的可能性。为了解决这个问题，人们开发了不同的策略，包括使用从食物中分离出的化合物，这些化合物已被研究以表征其作为天然膳食抗氧化剂的功效。目的：本研究的目的是展示多种天然化合物的有益作用及其对乙酰氨基酚诱导的肝毒性的作用。方法：检索PubMed数据库以汇编有关对APAP毒性具有肝保护作用的天然化合物的数据。结果与结论：结果描述了13种不同的具有抗APAP诱导肝毒性保护作用的食物来源化合物的健康促进特性以及肝保护所涉及的机制。
