在接受替诺福韦治疗期间，乙型肝炎病毒（HBV）在人类免疫缺陷病毒/乙型肝炎病毒合并感染中频繁复制。
Hepatitis B Virus (HBV) Replication During Tenofovir Therapy Is Frequent in Human Immunodeficiency Virus/HBV Coinfection.
作者信息
Hofmann Eveline, Surial Bernard, Boillat-Blanco Noémie, Günthard Huldrych F, Stöckle Marcel, Bernasconi Enos, Schmid Patrick, Calmy Alexandra, Suter-Riniker Franziska, Rauch Andri, Wandeler Gilles, Béguelin Charles
机构信息
Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
出版信息
Clin Infect Dis. 2023 Feb 18;76(4):730-733. doi: 10.1093/cid/ciac823.
In the Swiss HIV Cohort Study, 61 of 222 (27%) HIV-suppressed persons with chronic hepatitis B virus (HBV) infection had HBV replication after 2 years on tenofovir, of whom 77% were suppressed thereafter. Self-reported adherence to therapy and HBV viral load at tenofovir initiation were predictors of persistent replication.
在瑞士HIV队列研究中，222例接受抗逆转录病毒治疗且病毒得到抑制的慢性乙型肝炎病毒（HBV）感染者中，61例（27%）在使用替诺福韦治疗2年后出现HBV复制，其中77%的患者随后病毒得到抑制。自我报告的治疗依从性以及开始使用替诺福韦时的HBV病毒载量是持续复制的预测因素。
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