Hospital Medicine Section, Medicine Specialty Service, Durham VA Medical Center, Durham, North Carolina, USA.
Department of Physician Assistant Studies, The George Washington University School of Medicine and Health Sciences, Washington D.C., USA.
Clin Infect Dis. 2024 Sep 26;79(3):705-708. doi: 10.1093/cid/ciae241.
This case-control study explored cumulative tenofovir exposure among patients with human immunodeficiency virus/hepatis B virus (HIV/HBV) coinfection with HIV viral suppression. Among patients taking tenofovir disoproxil fumarate, median TFV-DP levels in dried blood spots were ∼3-fold lower among patients with incomplete HBV viral suppression (n = 4) compared to those with complete suppression (n = 5) (516 vs 1456 fmol/punch).
本病例对照研究探讨了 HIV 病毒抑制的 HIV/乙肝病毒(HBV)合并感染患者中替诺福韦累积暴露情况。在使用富马酸替诺福韦二吡呋酯的患者中,HBV 病毒抑制不完全(n = 4)的患者与完全抑制(n = 5)的患者相比,其血斑中 TFV-DP 水平中位数约低 3 倍(516 对 1456 fmol/点)。