• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Cumulative Tenofovir Exposure Among Patients With HIV/Hepatitis B Coinfection With Differential Viral Suppression.在 HIV/乙型肝炎共感染患者中,具有不同病毒抑制效果的累积替诺福韦暴露情况。
Clin Infect Dis. 2024 Sep 26;79(3):705-708. doi: 10.1093/cid/ciae241.
2
Hepatitis B virus (HBV) viremia despite tenofovir disoproxil fumarate-containing antiretroviral therapy in persons with HBV/HIV coinfection.尽管使用包含富马酸替诺福韦二吡呋酯的抗逆转录病毒疗法,乙型肝炎病毒(HBV)血症仍在乙型肝炎病毒/艾滋病病毒合并感染的人群中发生。
J Clin Virol. 2024 Dec;175:105733. doi: 10.1016/j.jcv.2024.105733. Epub 2024 Oct 2.
3
Lamivudine plus tenofovir versus lamivudine plus adefovir for the treatment of hepatitis B virus in HIV-coinfected patients, starting antiretroviral therapy.拉米夫定联合替诺福韦与拉米夫定联合阿德福韦用于治疗合并感染HIV且开始抗逆转录病毒治疗的乙肝病毒患者。
Indian J Med Microbiol. 2018 Apr-Jun;36(2):217-223. doi: 10.4103/ijmm.IJMM_17_37.
4
HBV genotypes and response to tenofovir disoproxil fumarate in HIV/HBV-coinfected persons.乙肝病毒基因型与替诺福韦酯对HIV/乙肝病毒合并感染患者的疗效
BMC Gastroenterol. 2015 Jul 8;15:79. doi: 10.1186/s12876-015-0308-0.
5
Association of tenofovir diphosphate and lamivudine triphosphate concentrations with HIV and hepatitis B virus viral suppression.替诺福韦二磷酸酯和拉米夫定三磷酸盐浓度与 HIV 和乙型肝炎病毒病毒抑制的关联。
AIDS. 2024 Mar 1;38(3):351-362. doi: 10.1097/QAD.0000000000003764. Epub 2023 Nov 22.
6
Pharmacogenetic determinants of tenofovir diphosphate and lamivudine triphosphate concentrations in people with HIV/HBV coinfection.HIV/HBV 合并感染人群中替诺福韦二磷酸和拉米夫定三磷酸浓度的药物遗传学决定因素。
Antimicrob Agents Chemother. 2024 Sep 4;68(9):e0054924. doi: 10.1128/aac.00549-24. Epub 2024 Jul 30.
7
Bictegravir/Emtricitabine/Tenofovir Alafenamide in Adults with HIV/HBV Coinfection: An Open-Label, Single-Arm, Safety and Efficacy Switch Study.比克替拉韦/恩曲他滨/丙酚替诺福韦用于成人HIV/ HBV合并感染:一项开放标签、单臂、安全性和有效性转换研究。
Viruses. 2025 Mar 31;17(4):510. doi: 10.3390/v17040510.
8
Long-term Hepatitis B and Liver Outcomes Among Adults Taking Tenofovir-Containing Antiretroviral Therapy for HBV/HIV Coinfection in Zambia.赞比亚接受含替诺福韦抗逆转录病毒疗法治疗HBV/HIV合并感染的成年人的长期乙肝及肝脏转归情况
Clin Infect Dis. 2024 Jun 14;78(6):1583-1590. doi: 10.1093/cid/ciad654.
9
Brief Report: Relationship Between ABCC4 SNPs and Hepatitis B Virus Suppression During Tenofovir-Containing Antiretroviral Therapy in Patients With HIV/HBV Coinfection.简要报告:在 HIV/HBV 合并感染患者中,使用含替诺福韦的抗逆转录病毒治疗期间,ABCC4 单核苷酸多态性与乙型肝炎病毒抑制之间的关系。
J Acquir Immune Defic Syndr. 2019 Dec 1;82(4):421-425. doi: 10.1097/QAI.0000000000002136.
10
HIV-HBV coinfection in Southern Africa and the effect of lamivudine- versus tenofovir-containing cART on HBV outcomes.南部非洲的 HIV-HBV 合并感染以及拉米夫定与替诺福韦为基础的 cART 对 HBV 结局的影响。
J Acquir Immune Defic Syndr. 2013 Oct 1;64(2):174-82. doi: 10.1097/QAI.0b013e3182a60f7d.

引用本文的文献

1
Hepatitis B virus (HBV) viremia despite tenofovir disoproxil fumarate-containing antiretroviral therapy in persons with HBV/HIV coinfection.尽管使用包含富马酸替诺福韦二吡呋酯的抗逆转录病毒疗法,乙型肝炎病毒(HBV)血症仍在乙型肝炎病毒/艾滋病病毒合并感染的人群中发生。
J Clin Virol. 2024 Dec;175:105733. doi: 10.1016/j.jcv.2024.105733. Epub 2024 Oct 2.

本文引用的文献

1
Hepatitis B Virus (HBV) Replication During Tenofovir Therapy Is Frequent in Human Immunodeficiency Virus/HBV Coinfection.在接受替诺福韦治疗期间,乙型肝炎病毒(HBV)在人类免疫缺陷病毒/乙型肝炎病毒合并感染中频繁复制。
Clin Infect Dis. 2023 Feb 18;76(4):730-733. doi: 10.1093/cid/ciac823.
2
Risk of HCC With Hepatitis B Viremia Among HIV/HBV-Coinfected Persons in North America.北美 HIV/HBV 共感染人群中乙型肝炎病毒血症与 HCC 风险。
Hepatology. 2021 Sep;74(3):1190-1202. doi: 10.1002/hep.31839. Epub 2021 Jun 22.
3
Intracellular Tenofovir-Diphosphate and Emtricitabine-Triphosphate in Dried Blood Spots Following Tenofovir Alafenamide: The TAF-DBS Study.替诺福韦艾拉酚胺治疗后干血斑中细胞内替诺福韦二磷酸和恩曲他滨三磷酸:TAF-DBS 研究。
J Acquir Immune Defic Syndr. 2020 Jul 1;84(3):323-330. doi: 10.1097/QAI.0000000000002354.
4
Development of tenofovir disoproxil fumarate resistance after complete viral suppression in a patient with treatment-naïve chronic hepatitis B: A case report and review of the literature.富马酸替诺福韦二吡呋酯耐药的发展在一个治疗初治慢性乙型肝炎患者病毒完全抑制后:病例报告和文献复习。
World J Gastroenterol. 2018 May 7;24(17):1919-1924. doi: 10.3748/wjg.v24.i17.1919.
5
Intracellular Tenofovir-Diphosphate and Emtricitabine-Triphosphate in Dried Blood Spots following Directly Observed Therapy.直接观察治疗后干血斑中细胞内替诺福韦二磷酸和恩曲他滨三磷酸
Antimicrob Agents Chemother. 2017 Dec 21;62(1). doi: 10.1128/AAC.01710-17. Print 2018 Jan.
6
Novel quantification of tenofovir disoproxil fumarate adherence in human immunodeficiency virus/hepatitis B coinfected patients with incomplete hepatitis B virus viral suppression.对人免疫缺陷病毒/乙型肝炎病毒合并感染且乙型肝炎病毒病毒抑制不完全患者中富马酸替诺福韦二吡呋酯依从性的新型定量分析
Hepatology. 2016 Sep;64(3):999-1000. doi: 10.1002/hep.28461. Epub 2016 Mar 18.
7
Persistent viremia in human immunodeficiency virus/hepatitis B coinfected patients undergoing long-term tenofovir: virological and clinical implications.慢性乙型肝炎病毒/人类免疫缺陷病毒合并感染患者长期应用替诺福韦治疗后持续性病毒血症:病毒学和临床意义。
Hepatology. 2014 Aug;60(2):497-507. doi: 10.1002/hep.27182. Epub 2014 Jun 20.
8
Incidence and risk factors for incomplete HBV DNA suppression in HIV/HBV-co-infected patients initiating tenofovir-based therapy.在开始使用替诺福韦治疗的 HIV/HBV 合并感染患者中,HBV DNA 抑制不完全的发生率和危险因素。
J Viral Hepat. 2014 Apr;21(4):288-96. doi: 10.1111/jvh.12142. Epub 2013 Jul 30.
9
Quantitation of tenofovir and emtricitabine in dried blood spots (DBS) with LC-MS/MS.采用 LC-MS/MS 定量检测干血斑中的替诺福韦和恩曲他滨。
J Pharm Biomed Anal. 2014 Jan;88:144-51. doi: 10.1016/j.jpba.2013.08.033. Epub 2013 Aug 31.
10
Tenofovir plasma concentrations according to companion drugs: a cross-sectional study of HIV-positive patients with normal renal function.替诺福韦血浆浓度与伴随药物的关系:肾功能正常的 HIV 阳性患者的横断面研究。
Antimicrob Agents Chemother. 2013 Apr;57(4):1840-3. doi: 10.1128/AAC.02434-12. Epub 2013 Feb 4.

在 HIV/乙型肝炎共感染患者中,具有不同病毒抑制效果的累积替诺福韦暴露情况。

Cumulative Tenofovir Exposure Among Patients With HIV/Hepatitis B Coinfection With Differential Viral Suppression.

机构信息

Hospital Medicine Section, Medicine Specialty Service, Durham VA Medical Center, Durham, North Carolina, USA.

Department of Physician Assistant Studies, The George Washington University School of Medicine and Health Sciences, Washington D.C., USA.

出版信息

Clin Infect Dis. 2024 Sep 26;79(3):705-708. doi: 10.1093/cid/ciae241.

DOI:10.1093/cid/ciae241
PMID:38703389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11426266/
Abstract

This case-control study explored cumulative tenofovir exposure among patients with human immunodeficiency virus/hepatis B virus (HIV/HBV) coinfection with HIV viral suppression. Among patients taking tenofovir disoproxil fumarate, median TFV-DP levels in dried blood spots were ∼3-fold lower among patients with incomplete HBV viral suppression (n = 4) compared to those with complete suppression (n = 5) (516 vs 1456 fmol/punch).

摘要

本病例对照研究探讨了 HIV 病毒抑制的 HIV/乙肝病毒(HBV)合并感染患者中替诺福韦累积暴露情况。在使用富马酸替诺福韦二吡呋酯的患者中,HBV 病毒抑制不完全(n = 4)的患者与完全抑制(n = 5)的患者相比,其血斑中 TFV-DP 水平中位数约低 3 倍(516 对 1456 fmol/点)。