肺癌术中分子影像学：综述
Intraoperative Molecular Imaging of Lung Cancer: A Review.
机构信息
Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Falk Building, Stanford, CA 94305, USA.
Division of Thoracic Surgery, Translational Research, Department of Surgery, University of Pennsylvania, 3400 Civic Center Boulevard, 14th Floor, PCAM South Tower, Philadelphia, PA, USA.
出版信息
Surg Oncol Clin N Am. 2022 Oct;31(4):685-693. doi: 10.1016/j.soc.2022.06.006. Epub 2022 Sep 27.
Intraoperative molecular imaging shows great promise in the surgical treatment of lung cancer, in particular tumor localization, margin assessment, identification of additional nodules, and even potentially lymph node assessment. Advances in imaging agents and fluorescence surgical cameras will be the key. Although no imaging agent is currently Food and Drug Administration approved, targeted, near-infrared agents such as OTL38 are in phase III trials.
术中分子成像在肺癌的外科治疗中具有广阔的应用前景，特别是在肿瘤定位、切缘评估、额外结节的识别，甚至潜在的淋巴结评估方面。成像试剂和荧光手术相机的进步将是关键。尽管目前还没有成像试剂获得美国食品和药物管理局的批准，但靶向近红外试剂，如 OTL38，正在进行 III 期临床试验。
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