一个独立的阶段？多聚（ADP-核糖）与 RNA 在生物分子凝聚物的组织中的作用。
A sePARate phase? Poly(ADP-ribose) versus RNA in the organization of biomolecular condensates.
机构信息
Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk 630090, Russia.
Novosibirsk State University, Novosibirsk 630090, Russia.
出版信息
Nucleic Acids Res. 2022 Oct 28;50(19):10817-10838. doi: 10.1093/nar/gkac866.
Condensates are biomolecular assemblies that concentrate biomolecules without the help of membranes. They are morphologically highly versatile and may emerge via distinct mechanisms. Nucleic acids-DNA, RNA and poly(ADP-ribose) (PAR) play special roles in the process of condensate organization. These polymeric scaffolds provide multiple specific and nonspecific interactions during nucleation and 'development' of macromolecular assemblages. In this review, we focus on condensates formed with PAR. We discuss to what extent the literature supports the phase separation origin of these structures. Special attention is paid to similarities and differences between PAR and RNA in the process of dynamic restructuring of condensates during their functioning.
凝聚物是生物分子聚集物，无需膜的帮助即可浓缩生物分子。它们在形态上具有高度的多功能性，可能通过不同的机制出现。核酸-DNA、RNA 和聚（ADP-核糖）（PAR）在凝聚物组织过程中发挥特殊作用。这些聚合支架在大分子组装的成核和“发育”过程中提供多种特异性和非特异性相互作用。在这篇综述中，我们专注于形成 PAR 的凝聚物。我们讨论文献在多大程度上支持这些结构的相分离起源。特别关注 PAR 和 RNA 在凝聚物功能过程中动态重构期间的相似性和差异。
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