Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Biomater Adv. 2022 Nov;142:213151. doi: 10.1016/j.bioadv.2022.213151. Epub 2022 Oct 12.
Microneedles (MNs) have attracted the interest of researchers. Polymeric MNs offer tremendous promise as drug delivery vehicles for bio-applications because of their high loading capacity, strong patient adherence, excellent biodegradability and biocompatibility, low toxicity, and extremely cheap cost. Incorporating enhanced-property nanomaterials into polymeric MNs matrix increases their features such as better mechanical strength, sustained drug delivery, lower toxicity, and higher therapeutic effects, therefore considerably increasing their biomedical application. This paper discusses polymeric MN fabrication techniques and the present status of polymeric MNs as a delivery method for enhanced drug delivery in cancer therapeutic applications. Furthermore, the opportunities and challenges of polymeric MNs for improved drug delivery in cancer therapy are highlighted.
微针 (MNs) 引起了研究人员的兴趣。由于其高载药量、较强的患者依从性、出色的生物降解性和生物相容性、低毒性以及极其低廉的成本，聚合物 MNs 作为生物应用的药物输送载体具有巨大的潜力。将具有增强性能的纳米材料纳入聚合物 MNs 基质中，可提高其机械强度、持续药物输送、降低毒性和提高治疗效果等特性，从而极大地增加了它们在生物医学中的应用。本文讨论了聚合物 MN 的制造技术以及聚合物 MN 作为增强药物输送方法在癌症治疗中的应用现状。此外，还强调了聚合物 MN 在癌症治疗中改善药物输送的机遇和挑战。
