Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Rampuram, Chennai, 87, India.
Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 14, Tamil Nadu, India.
Environ Res. 2023 Jan 1;216(Pt 2):114475. doi: 10.1016/j.envres.2022.114475. Epub 2022 Oct 14.
Non-enzymatic glycation of biomolecules results in advanced glycation end products (AGEs), which are responsible for secondary complications in diabetes. Inhibiting methyl glyoxal (MGO) induced advanced glycation end product (AGE) formation is the only way to alleviate diabetic complications. This study aimed to look into the abilities of herbal extract Kigelia africana and K. africana synthesized zinc oxide nanoparticles (ZnONPs) to inhibit the emergence of MG-derived AGEs. The study intended to determine antioxidant and AGE inhibition of the plant extract and ZnONPs. ZnONPs were tested for the efficiency of anti-diabetic activity in streptozotocin-induced diabetic Wister rats. We discovered that the MGO-trapping effects on the prevention of AGE production were mediated by the downregulation of the amplification of MGO-trapping impacts on the hypoglycemic and antihyperlipidemic mechanisms of ZnONPs. According to histological findings, the treatment with ZnONPs also successfully lowers inflammation in the hepatic and renal tissues. Overall, future mechanistic research could establish ZnONPs potential anti-diabetic properties.
生物分子的非酶糖化会导致晚期糖基化终产物（AGEs）的形成，这是糖尿病继发并发症的罪魁祸首。抑制甲基乙二醛（MGO）诱导的晚期糖基化终产物（AGE）的形成是缓解糖尿病并发症的唯一途径。本研究旨在研究草药提取物 Kigelia africana 和 K. africana 合成的氧化锌纳米粒子（ZnONPs）抑制 MG 衍生 AGE 形成的能力。本研究旨在确定植物提取物和 ZnONPs 的抗氧化和 AGE 抑制作用。ZnONPs 被测试了其在链脲佐菌素诱导的糖尿病 Wister 大鼠中的抗糖尿病活性。我们发现，通过下调 MGO 捕获对 ZnONPs 的降血糖和抗高血脂机制的放大影响，ZnONPs 对 MGO 捕获效应具有抗 AGE 生成作用。根据组织学发现，ZnONPs 的治疗还成功降低了肝和肾组织中的炎症。总的来说，未来的机制研究可以确定 ZnONPs 的潜在抗糖尿病特性。
