School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong 518107, China.
School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong 518107, China.
Sci Total Environ. 2023 Jan 20;857(Pt 2):159449. doi: 10.1016/j.scitotenv.2022.159449. Epub 2022 Oct 13.
Polycyclic aromatic hydrocarbons (PAHs) pose significant health risks. However, no nationwide cohort has been established to consistently record biomonitoring data on PAH exposure in the Chinese population. Biomonitoring data from 56 published studies were combined in this study to develop a profile of urinary PAH metabolites among Chinese population in the 2010s. The stacked column charts described the composition profiles of hydroxylated PAHs (OH-PAHs) in general, special, and occupational populations. Hydroxynaphthalene (OH-Nap) and hydroxyfluorene (OH-Flu) accounted for more than half of the urinary OH-PAH in general and special populations. The urine of the occupational populations contained a significant amount of hydroxyphenanthrene (OH-Phe) and 1-hydroxypyrene (1-OHPyr). Furthermore, this study analyzed the distribution profiles of non-occupationally exposed populations, such as spatial distribution, age distribution, and trends over time. The population of the Southern region had higher urinary OH-PAH concentrations than the population of the Northern region. Adults (45-55 years old) had the highest level of internal PAH exposure. Between 2010 and 2018, the overall trend of urinary OH-PAHs in Chinese general populations decreased. The cumulative distribution function (CDF) revealed that 1-OHNap and 1-OHPyr were better at distinguishing internal PAH exposure among different populations. The sum of OH-Flu and OH-Phe in urine can be used to assess the impact of indoor and outdoor environments on human exposure to PAHs. Our findings suggest that more emphasis should be placed on collecting biomonitoring data for adults of all ages (particularly in the Northern region) and vulnerable populations. In conclusion, this study advocates for the establishment of a nationwide cohort study of Chinese populations as soon as possible in the future to evaluate the Chinese population's exposure to environmental contaminants.
多环芳烃（PAHs）对健康构成重大风险。然而，目前尚未建立全国性队列来持续记录中国人群中 PAH 暴露的生物监测数据。本研究将 56 项已发表研究的生物监测数据进行了合并，以构建 2010 年代中国人群尿液中 PAH 代谢物的特征。堆积柱形图描述了一般人群、特殊人群和职业人群中羟基多环芳烃（OH-PAHs）的组成特征。羟基萘（OH-Nap）和羟基芴（OH-Flu）在一般人群和特殊人群的尿液中占 OH-PAH 的一半以上。职业人群尿液中含有大量的羟基菲（OH-Phe）和 1-羟基芘（1-OHPyr）。此外，本研究还分析了非职业暴露人群的分布特征，如空间分布、年龄分布和随时间的变化趋势。南部地区人群的尿液 OH-PAH 浓度高于北部地区人群。成年人（45-55 岁）体内 PAH 暴露水平最高。2010 年至 2018 年期间，中国一般人群尿液中 OH-PAH 的整体趋势呈下降趋势。累积分布函数（CDF）表明，1-OHNap 和 1-OHPyr 更能区分不同人群的体内 PAH 暴露情况。尿液中 OH-Flu 和 OH-Phe 的总和可用于评估室内外环境对人体暴露于 PAHs 的影响。研究结果表明，应更加重视收集各年龄段成年人（特别是北方地区）和弱势群体的生物监测数据。总之，本研究提倡尽快在中国建立全国性的人群队列研究，以评估中国人群对环境污染物的暴露情况。
