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大多数静脉血栓栓塞事件应发生在低风险美容手术患者中:一项模拟研究。

The Majority of Venous Thromboembolism Events Should Occur in Lower Risk Aesthetic Surgery Patients: A Simulation Study.

作者信息

Pannucci Christopher J, Momeni Arash, Januszyk Michael

机构信息

Plastic Surgery Northwest, Spokane, Wash.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, Calif.

出版信息

Plast Reconstr Surg Glob Open. 2022 Oct 11;10(10):e4573. doi: 10.1097/GOX.0000000000004573. eCollection 2022 Oct.

Abstract

UNLABELLED

Evidence-based venous thromboembolism (VTE) prevention among aesthetic patients is lacking. This study seeks to (1) quantify 2005 Caprini scores in primary breast augmentation patients, (2) determine the proportion of patients with potentially modifiable VTE risk factors, and (3) project, using Monte Carlo simulation, the expected distribution of Caprini scores among aesthetic surgery patients who develop VTE.

METHODS

The observational study (part 1) screened consecutive primary breast augmentation patients for VTE risk using the 2005 Caprini score. Aggregate scores were compiled, and the proportion of patients with potentially modifiable risk factors were identified. Part 2 used Monte Carlo simulation to generate risk score distributions for VTE events predicted to occur among randomly sampled patient cohorts with baseline Caprini risk profiles derived from the part 1 data.

RESULTS

One hundred patients had mean age of 35.7 years and mean body mass index of 23.8 kg/m. Median 2005 Caprini score was 3 (range, 2-8), with the majority (96%) having scores of ≤6. Twenty-eight percent of patients had at least one potentially modifiable risk factor or risk factor potentially benefiting from further investigation. Monte Carlo simulations demonstrated that for a population with 96% Caprini ≤6 (and 4% Caprini ≥7), 80% of VTE events would be expected to occur in patients with Caprini scores ≤6.

CONCLUSIONS

The majority of breast augmentation patients in this study (96%) have 2005 Caprini scores ≤6. Twenty-eight percent of patients have potentially modifiable risk factors. The majority of patients with VTE after aesthetic surgery are expected to have lower Caprini risk scores.

摘要

未标注

美容手术患者中基于证据的静脉血栓栓塞症(VTE)预防措施尚不完善。本研究旨在:(1)量化初次隆胸患者的2005年卡普里尼评分;(2)确定具有潜在可改变VTE风险因素的患者比例;(3)使用蒙特卡洛模拟法预测发生VTE的美容手术患者中卡普里尼评分的预期分布情况。

方法

观察性研究(第1部分)使用2005年卡普里尼评分对连续的初次隆胸患者进行VTE风险筛查。汇总得分,并确定具有潜在可改变风险因素的患者比例。第2部分使用蒙特卡洛模拟法,为从第1部分数据得出的具有基线卡普里尼风险特征的随机抽样患者队列中预计发生的VTE事件生成风险评分分布。

结果

100名患者的平均年龄为35.7岁,平均体重指数为23.8kg/m²。2005年卡普里尼评分中位数为3(范围为2 - 8),大多数(96%)患者评分≤6。28%的患者至少有一个潜在可改变的风险因素或可能受益于进一步调查的风险因素。蒙特卡洛模拟表明,对于96%卡普里尼评分≤6(4%卡普里尼评分≥7)的人群,预计80%的VTE事件将发生在卡普里尼评分≤6的患者中。

结论

本研究中大多数隆胸患者(96%)的2005年卡普里尼评分≤6。28%的患者具有潜在可改变的风险因素。预计美容手术后发生VTE的大多数患者卡普里尼风险评分较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a0/9556122/25e078ead633/gox-10-e4573-g001.jpg

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