Wan Huanzhi, Zhang Yuanyuan, Hua Qingquan
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Research Institute of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Front Cell Neurosci. 2022 Sep 30;16:966202. doi: 10.3389/fncel.2022.966202. eCollection 2022.
Sensorineural hearing loss (SNHL) is currently a major health issue. As one of the most common neurodegenerative diseases, SNHL is associated with the degradation of hair cells (HCs), spiral ganglion neurons (SGNs), the stria vascularis, supporting cells and central auditory system cells. Autophagy is a highly integrated cellular system that eliminates impaired components and replenishes energy to benefit cellular homeostasis. Etiological links between autophagy alterations and neurodegenerative diseases, such as SNHL, have been established. The hearing pathway is complex and depends on the comprehensive functions of many types of tissues and cells in auditory system. In this review, we discuss the roles of autophagy in promoting and inhibiting hearing, paying particular attention to specific cells in the auditory system, as discerned through research. Hence, our review provides enlightening ideas for the role of autophagy in hearing development and impairment.
感音神经性听力损失（SNHL）目前是一个主要的健康问题。作为最常见的神经退行性疾病之一，SNHL与毛细胞（HCs）、螺旋神经节神经元（SGNs）、血管纹、支持细胞和中枢听觉系统细胞的退化有关。自噬是一个高度整合的细胞系统，它清除受损成分并补充能量以维持细胞稳态。自噬改变与神经退行性疾病（如SNHL）之间的病因学联系已经确立。听觉通路很复杂，依赖于听觉系统中多种组织和细胞的综合功能。在这篇综述中，我们讨论自噬在促进和抑制听力方面的作用，特别关注通过研究识别出的听觉系统中的特定细胞。因此，我们的综述为自噬在听力发育和损伤中的作用提供了有启发性的观点。
