炎症细胞因子对儿童幽门螺杆菌感染根除及复发的影响。
Effects of inflammatory cytokines on eradication and recurrence of Helicobacter pylori infection in children.
作者信息
Zhang Sisi, Zhang Yuanda, Chen Songsong, Teng Yongnan, Li Chen
机构信息
Sisi Zhang, Department of Gastroenterology, Baoding Children's Hospital, Baoding, Hebei, 071000, P.R. China. Key Laborary of Clinical Research on Respiratory Digestive Disease, Hebei Baoding, 071000, China.
Yuanda Zhang, Department of Gastroenterology, Baoding Children's Hospital, Baoding, Hebei, 071000, P.R. China. Key Laborary of Clinical Research on Respiratory Digestive Disease, Hebei Baoding, 071000, China.
出版信息
Pak J Med Sci. 2022 Sep-Oct;38(7):1883-1887. doi: 10.12669/pjms.38.7.5281.
OBJECTIVES
To study the correlation of eradication and recurrence with IL-1 β, IL-6 and TNF-α levels in children with Helicobacter pylori (Hp) infection.
METHODS
Children confirmed with Hp infection (n = 153) in our hospital from January to June 2019 and successfully followed up for one year were selected as the study subjects, and 73 healthy children of the same period were selected as the control group. The levels of IL-1 β, IL-6 and TNF-α in children confirmed with Hp infection and healthy children were detected, respectively.
RESULTS
Results of triple therapy: 113 cases (73.9%) reexamined with negative 13C-urea breath test were included in Group-A; and 40 cases (26.1%) reexamined with positive 13C-urea breath test were included in Group-B. Follow up results: 23 cases (20.4%) positive in 13C-urea breath test in one year follow-up were included in Group-C; and 90 cases (79.6%) negative in 13C-urea breath test in one year follow-up were included in Group-D. Group-B showed significantly higher levels of IL-1β, IL-6 and TNF-α when compared with the Group-A and the control group, respectively ( < 0.05). Obviously higher levels of IL-1β, IL-6 and TNF-α were observed in Group-C and Group-D in comparison with the control group ( < 0.05). There was no significant difference in IL-1 β level between Group-C and Group-D ( > 0.05). IL-6 and TNF-α levels in Group-C were remarkably higher than those in Group-D ( < 0.05).
CONCLUSIONS
Higher levels of IL-1β, IL-6 and TNF-α may affect the eradication effect of triple therapy in Children with Hp infection, and increased levels of IL-6 and TNF-α may affect the recurrence rate of Hp infection in children.
目的
研究幽门螺杆菌（Hp）感染儿童中白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平与根除及复发的相关性。
方法
选取2019年1月至6月在我院确诊为Hp感染且成功随访1年的儿童153例作为研究对象，同期选取73例健康儿童作为对照组。分别检测确诊为Hp感染儿童及健康儿童的IL-1β、IL-6和TNF-α水平。
结果
三联疗法结果：13C-尿素呼气试验复查阴性的113例（73.9%）纳入A组；13C-尿素呼气试验复查阳性的40例（26.1%）纳入B组。随访结果：1年随访中13C-尿素呼气试验阳性的23例（20.4%）纳入C组；1年随访中13C-尿素呼气试验阴性的90例（79.6%）纳入D组。B组的IL-1β、IL-6和TNF-α水平分别显著高于A组和对照组（P<0.05）。C组和D组的IL-1β、IL-6和TNF-α水平明显高于对照组（P<0.05）。C组和D组的IL-1β水平差异无统计学意义（P>0.05）。C组的IL-6和TNF-α水平显著高于D组（P<0.05）。
结论
较高水平的IL-1β、IL-6和TNF-α可能影响Hp感染儿童三联疗法的根除效果，而IL-6和TNF-α水平升高可能影响儿童Hp感染的复发率。
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