Zhou Ying, Ye Ziqing, Huang Jie, Huang Ying, Yan Weili, Zhang Yi
Department of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.
Department of Clinical Epidemiology, Children's Hospital of Fudan University, Shanghai, China.
Acta Paediatr. 2018 Sep;107(9):1624-1628. doi: 10.1111/apa.14387. Epub 2018 May 29.
Helicobacter pylori infections mainly occur during childhood and may cause chronic diseases and persist for life unless they are treated. The aim of this study was to identify the prevalence and infection status of H. pylori infection among schoolchildren.
We conducted a cross-sectional study of 867 children (52% male) aged 7-12 years in a primary school in the Minhang District of Shanghai, China, in 2014, and a one-year follow-up study of 352 subjects. The 13C-urea breath test was used to identify the H. pylori infection at baseline and one year later. A parental questionnaire provided information regarding the children's socioeconomic status and household environment.
The overall prevalence of the H. pylori infection was 24.1% (209/867), with a 95% confidence interval of 21.3% to 27.0%. The one-year follow-up study of 352 subjects found that 33.5% were positive for the infection at baseline and 66.5% were negative. We found that 27.1% of the positive cases recovered and 8.9% of the negative cases acquired the infection during the year. The spontaneous eradication rate was only 2.9% over the one-year period.
The prevalence of the H. pylori infection among Chinese schoolchildren aged 7-12 was high and spontaneous eradication was low.
幽门螺杆菌感染主要发生在儿童期，可能导致慢性疾病，若不治疗则会终身持续存在。本研究的目的是确定学龄儿童中幽门螺杆菌感染的患病率和感染状况。
2014年，我们在中国上海闵行区的一所小学对867名7至12岁的儿童（52%为男性）进行了横断面研究，并对352名受试者进行了为期一年的随访研究。采用13C尿素呼气试验在基线和一年后确定幽门螺杆菌感染情况。一份家长问卷提供了有关儿童社会经济地位和家庭环境的信息。
幽门螺杆菌感染的总体患病率为24.1%（209/867），95%置信区间为21.3%至27.0%。对352名受试者进行的一年随访研究发现，基线时33.5%的人感染呈阳性，66.5%呈阴性。我们发现，在这一年中，27.1%的阳性病例康复，8.9%的阴性病例感染。一年期间自发根除率仅为2.9%。
7至12岁中国学龄儿童中幽门螺杆菌感染率高，自发根除率低。
