幽门螺杆菌感染相关性胃炎患儿的根除、复发情况及25-羟基维生素D和白细胞介素-1β水平分析

Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis.

作者信息

Zhang Yuanda, Bi Binbin, Guo Xu, Zhang Shaohui

机构信息

Yuanda Zhang, Department of Gastroenterology, Baoding Children's Hospital, Baoding, Hebei, 071000, P.R. China; Key Laboratory for Clinical Research of Respiratory and Digestive Diseases in Children, Baoding, Hebei, 071000, China.

Binbin Bi, Department of Gastroenterology, Baoding Children's Hospital, Baoding, Hebei, 071000, P.R. China; Key Laboratory for Clinical Research of Respiratory and Digestive Diseases in Children, Baoding, Hebei, 071000, China.

出版信息

Pak J Med Sci. 2020 Sep-Oct;36(6):1377-1381. doi: 10.12669/pjms.36.6.2292.

DOI:10.12669/pjms.36.6.2292

PMID:32968412

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7501042/

Abstract

OBJECTIVE

To study whether the levels of 25-hydroxyvitamin D (25-(OH)D) and Interleukin-1β (IL-1β) are correlated to the eradication and recurrence of helicobacter pylori (Hp) in paediatric patients with Hp infection-related gastritis.

METHODS

A total of 142 paediatric patients with Hp infection-related gastritis from November 2017 to March 2018 in Baoding Children's Hospital were selected as study subjectswere selected as study subjects and were followed up for one year. Paediatric patients were grouped and analyzed according to the effect of follow-up treatment and recurrence.

RESULTS

The levels of 25-(OH) D in the non-eradication group were lower than those in the eradication group and the control group (F=27.087, P<0.05); the levels of IL-1β were higher than those in the eradication group and the control group (F=16.610, P<0.05). Recurrence during follow-up visits: The levels of 25-(OH) D in the recurrence group were lower than those in the non-recurrence group and the control group (F=33.837, P<0.05); the levels of IL-1β in the recurrence group were higher than those in the non-recurrence group and the control group (F=7.896, P<0.05). Correlation analysis showed the levels of 25-(OH) D and IL-1β in the eradication group and the non-eradication group were negatively correlated (r=-0.232, P<0.05); the levels of 25-(OH) D and IL-1β in the recurrence group and the non-recurrence group were negatively correlated (r=-0.225, P<0.05).

CONCLUSION

Relatively high levels of IL-1β may be correlated to the difficulty in eradicating the Hp infection in paediatric patients. Relatively low levels of 25-(OH) D may be correlated to the difficulty in eradicating the Hp infection and recurrence in paediatric patients.

摘要

目的

研究25-羟基维生素D（25-(OH)D）和白细胞介素-1β（IL-1β）水平与幽门螺杆菌（Hp）感染相关性胃炎患儿中Hp根除及复发的关系。

方法

选取2017年11月至2018年3月在保定市儿童医院就诊的142例Hp感染相关性胃炎患儿作为研究对象，并进行为期一年的随访。根据随访治疗效果及复发情况对患儿进行分组分析。

结果

未根除组的25-(OH)D水平低于根除组和对照组（F=27.087，P<0.05）；IL-1β水平高于根除组和对照组（F=16.610，P<0.05）。随访期间复发情况：复发组的25-(OH)D水平低于未复发组和对照组（F=33.837，P<0.05）；复发组的IL-1β水平高于未复发组和对照组（F=7.896，P<0.05）。相关性分析显示，根除组和未根除组中25-(OH)D与IL-1β水平呈负相关（r=-0.232，P<0.05）；复发组和未复发组中25-(OH)D与IL-1β水平呈负相关（r=-0.225，P<；0.05）。