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非酒精性脂肪性肝硬化中的罕见瘦素：一例报告

Rare leptin in non-alcoholic fatty liver cirrhosis: A case report.

作者信息

Nong Yao-Bin, Huang Hong-Na, Huang Jing-Jing, Du Yuan-Qin, Song Wen-Xuan, Mao De-Wen, Zhong Yue-Xue, Zhu Rong-Huo, Xiao Xi-Yu, Zhong Rui-Xi

机构信息

The First Clinical Medical College, Guangxi University of Chinese Medicine, Nanning 530022, Guangxi Zhuang Autonomous Region, China.

Department of Internal Medicine of Traditional Chinese Medicine,The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530022, Guangxi Zhuang Autonomous Region, China.

出版信息

World J Clin Cases. 2022 Oct 6;10(28):10293-10300. doi: 10.12998/wjcc.v10.i28.10293.

DOI:10.12998/wjcc.v10.i28.10293
PMID:36246792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9561580/
Abstract

BACKGROUND

Non-alcoholic fatty liver disease (NAFLD)-related cirrhosis is mainly caused by NAFLD by causing inflammation which leads to fibrosis. The role of leptin in NAFLD-related cirrhosis has been rarely reported.

CASE SUMMARY

This study presents the case of a 65-year-old male patient who was referred to The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, China, for diagnosis and treatment for liver cirrhosis. Initially, the cause of liver cirrhosis was unknown. After radiology, laboratory examination, pathological results and analysis of the patient's signs and symptoms, the case was finally diagnosed with final NAFLD-related cirrhosis. Although this study reports a single case, the findings might expand the understanding of leptin's role in NAFLD-related cirrhosis and might provide a basis for the clinical diagnostic criteria, pathological features and treatment of NAFLD-related cirrhosis.

CONCLUSION

Although the occurrence of marasmus NAFLD-related cirrhosis is rare, it needs to be distinguished from other liver diseases, including viral hepatitis, drug-induced liver disease, Wilson's disease and autoimmune liver disease. Aggressive treatment is needed to prevent the progression of NAFLD-related cirrhosis.

摘要

背景

非酒精性脂肪性肝病（NAFLD）相关肝硬化主要由NAFLD引发炎症进而导致纤维化所致。瘦素在NAFLD相关肝硬化中的作用鲜有报道。

病例摘要

本研究报告了一名65岁男性患者的病例，该患者因肝硬化被转诊至中国广西中医药大学第一附属医院进行诊断和治疗。起初，肝硬化病因不明。经过影像学检查、实验室检查、病理结果以及对患者体征和症状的分析，最终确诊为NAFLD相关肝硬化。尽管本研究报告的是单个病例，但这些发现可能会拓宽对瘦素在NAFLD相关肝硬化中作用的认识，并可能为NAFLD相关肝硬化的临床诊断标准、病理特征及治疗提供依据。

结论

尽管消瘦型NAFLD相关肝硬化的发生较为罕见，但需要与其他肝病相鉴别，包括病毒性肝炎、药物性肝病、威尔逊病和自身免疫性肝病。需要积极治疗以防止NAFLD相关肝硬化的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a903/9561580/33c35658db13/WJCC-10-10293-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a903/9561580/5b729fcbe283/WJCC-10-10293-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a903/9561580/aadc5947cd67/WJCC-10-10293-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a903/9561580/2c52844067ab/WJCC-10-10293-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a903/9561580/33c35658db13/WJCC-10-10293-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a903/9561580/5b729fcbe283/WJCC-10-10293-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a903/9561580/aadc5947cd67/WJCC-10-10293-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a903/9561580/2c52844067ab/WJCC-10-10293-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a903/9561580/33c35658db13/WJCC-10-10293-g004.jpg

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