Loor Jamie M, Judd Nila S, Rice Claudia M, Perea Diana D, Croswell Emilee, Singh Pooja P, Unruh Mark, Zhu Yiliang, Sehgal Ashwini R, Goff Sarah L, Bryce Cindy L, Myaskovsky Larissa
Center for Healthcare Equity in Kidney Disease (CHEK-D), University of New Mexico Health Science Center, United States.
Department of Psychiatry, University of Pittsburgh, United States.
Contemp Clin Trials Commun. 2022 Oct 4;30:101015. doi: 10.1016/j.conctc.2022.101015. eCollection 2022 Dec.
Kidney transplant (KT) is the optimal treatment for kidney failure (KF), and although completion of KT evaluation is an essential step in gaining access to transplantation, the process is lengthy, time consuming, and burdensome. Furthermore, despite similar referral rates to non-Hispanic Whites, both Hispanic/Latinos and American Indians are less likely to be wait-listed or to undergo KT.
The Access to Kidney Transplantation in Minority Populations (AKT-MP) Trial compares two patient-centered methods to facilitate KT evaluation: kidney transplant fast track (KTFT), a streamlined KT evaluation process; and peer navigators (PN), a peer-assisted evaluation program that incorporates motivational interviewing. This pragmatic randomized trial will use a comparative effectiveness approach to assess whether KTFT or PN can help patients overcome barriers to transplant listing. We will randomly assign patients to the two conditions. We will track participants' medical records and conduct surveys prior to their initial evaluation clinic visit and again after they complete or discontinue evaluation.
Our aims are to (1) compare KTFT and PN to assess improvements in kidney transplant (KT) related outcomes and cost effectiveness; (2) examine how each approach effects changes in cultural/contextual factors, KT concerns, KT knowledge, and KT ambivalence; and (3) develop a framework for widespread implementation of either approach. The results of this trial will provide key information for facilitating the evaluation process, improving patient care, and decreasing disparities in KT.
肾移植(KT)是肾衰竭(KF)的最佳治疗方法,尽管完成肾移植评估是获得移植机会的关键一步,但这个过程漫长、耗时且负担沉重。此外,尽管西班牙裔/拉丁裔和美国印第安人与非西班牙裔白人的转诊率相似,但他们被列入等待名单或接受肾移植的可能性较小。
少数族裔人群肾移植准入(AKT-MP)试验比较了两种以患者为中心的促进肾移植评估的方法:肾移植快速通道(KTFT),一种简化的肾移植评估流程;以及同伴导航员(PN),一个采用动机性访谈的同伴辅助评估项目。这项务实的随机试验将采用比较有效性方法来评估KTFT或PN是否能帮助患者克服移植登记的障碍。我们将把患者随机分配到这两种情况中。我们将跟踪参与者的病历,并在他们首次评估门诊就诊前以及完成或停止评估后再次进行调查。
我们的目标是:(1)比较KTFT和PN,以评估肾移植(KT)相关结果的改善情况和成本效益;(2)研究每种方法如何影响文化/背景因素、肾移植相关担忧、肾移植知识和肾移植矛盾心理的变化;(3)为广泛实施这两种方法之一制定一个框架。这项试验的结果将为促进评估过程、改善患者护理以及减少肾移植差异提供关键信息。