Sun Liya, Xu Manfei, Shi Yongyong, Xu Yifeng, Chen Jinghong, He Lin
Shanghai Mental Health Center Editorial Office, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Gen Psychiatr. 2022 Sep 22;35(4):e100889. doi: 10.1136/gpsych-2022-100889. eCollection 2022.
The mind has puzzled humans for centuries, and its disorders, such as psychoses, have caused tremendous difficulties. However, relatively recent biotechnological breakthroughs, such as DNA technology and neuroimaging, have empowered scientists to explore the more fundamental aspects of psychosis. From searching for psychosis-causing genes to imaging the depths of the brain, scientists worldwide seek novel methods to understand the mind and the causes of its disorders. This article will briefly review the history of understanding and managing psychosis and the main findings of modern genetic research and then attempt to stimulate thought for decoding the biological mechanisms of psychosis in the present era of brain science.
几个世纪以来,人类一直对心智感到困惑,而诸如精神病等心智障碍带来了巨大困难。然而,诸如DNA技术和神经成像等相对较新的生物技术突破,使科学家有能力探索精神病更基本的方面。从寻找导致精神病的基因到对大脑深处进行成像,世界各地的科学家都在寻求新方法来理解心智及其障碍的成因。本文将简要回顾理解和治疗精神病的历史以及现代遗传学研究的主要发现,然后尝试在当今脑科学时代激发对解读精神病生物学机制的思考。