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1例近期接种严重急性呼吸综合征冠状病毒2（SARS-CoV-2）灭活疫苗后发生的无菌性双侧海绵窦血栓形成病例。

A case of aseptic bilateral cavernous sinus thrombosis following a recent inactivated SARS-CoV-2 vaccination.

作者信息

Nusanti Syntia, Putera Ikhwanuliman, Sidik M, Edwar Lukman, Koesnoe Sukamto, Rachman Andhika, Kurniawan Mohammad, Edi Tarigan Tri Juli, Yunus Reyhan Eddy, Saraswati Indah, Zoraida Soraya Siti Halida, Pratomo Tiara Grevillea, Nora Rina La Distia

机构信息

Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Kirana Eye Hospital, Jakarta, Indonesia.

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.

出版信息

Taiwan J Ophthalmol. 2022 Jun 15;12(3):334-338. doi: 10.4103/tjo.tjo_25_22. eCollection 2022 Jul-Sep.

DOI:10.4103/tjo.tjo_25_22
PMID:36248079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9558469/
Abstract

This case report aims to describe the first report of bilateral aseptic cavernous sinus thrombosis (CST) with a recent history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. A 50-year-old woman presented with bilateral proptosis, decreased vision, and ophthalmoplegia 16 days following CoronaVac vaccine. The visual acuity of the left eye was 20/150, while the right eye was no light perception with a hyperemic optic nerve head. She had a history of hyperthyroidism and currently on warfarin consumption. Laboratory results depicted elevated free T4, free T3, international normalized ratio, and low protein S and C. Magnetic resonance imaging showed bilateral CST, and high-dose methylprednisolone along with fondaparinux was given. The symptoms were significantly resolved, with the visual acuity of the left eye being improved to 20/20 but not the right eye. Bilateral CST has not been previously reported following inactivated SARS-CoV-2 vaccination. The underlying systemic conditions should be taken into consideration for the possibility of the inactivated SARS-CoV-2 vaccine-related event.

摘要

本病例报告旨在描述首例有严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗近期接种史的双侧无菌性海绵窦血栓形成（CST）。一名50岁女性在接种科兴疫苗16天后出现双侧眼球突出、视力下降和眼肌麻痹。左眼视力为20/150，而右眼无光感，视神经乳头充血。她有甲状腺功能亢进病史，目前正在服用华法林。实验室检查结果显示游离T4、游离T3升高，国际标准化比值升高，蛋白S和C降低。磁共振成像显示双侧CST，给予大剂量甲泼尼龙和磺达肝癸钠。症状明显缓解，左眼视力提高到20/20，但右眼未改善。此前尚无灭活SARS-CoV-2疫苗接种后双侧CST的报道。对于灭活SARS-CoV-2疫苗相关事件的可能性，应考虑潜在的全身状况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0746/9558469/a96d5019a0db/TJO-12-334-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0746/9558469/9c41969cee78/TJO-12-334-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0746/9558469/183487322fa6/TJO-12-334-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0746/9558469/869b89be44f4/TJO-12-334-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0746/9558469/a96d5019a0db/TJO-12-334-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0746/9558469/9c41969cee78/TJO-12-334-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0746/9558469/183487322fa6/TJO-12-334-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0746/9558469/869b89be44f4/TJO-12-334-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0746/9558469/a96d5019a0db/TJO-12-334-g004.jpg

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