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加拿大阿片类药物危机期间药物过量死亡率的意外变化。

Unanticipated Changes in Drug Overdose Death Rates in Canada During the Opioid Crisis.

作者信息

Snowdon John, Choi Namkee

机构信息

Discipline of Psychiatry, Sydney Medical School, Sydney, NSW Australia.

Centre for Mental Health, Concord Hospital, Concord, NSW 2139 Australia.

出版信息

Int J Ment Health Addict. 2022 Oct 10:1-19. doi: 10.1007/s11469-022-00932-9.

DOI:10.1007/s11469-022-00932-9
PMID:36248265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9550153/
Abstract

Escalating drug overdose death rates in Canada are of ever-increasing concern. To better understand the extent of this health threat, we obtained mortality statistics and population figures for the years 2000 to 2020, and examined rates of overdose deaths, coded (using ICD-10) as accidental, suicide or "undetermined intent." The drug deemed as primarily responsible for the death was categorized as opioid, non-opioid, or unspecified. Age patterns of drug deaths were graphed. Joinpoint analysis was used to test the significance of changes in death rates. Accidental opioid and stimulant overdose death rates in Canada have climbed faster since 2011, though not as high as corresponding US rates. Unknown cause death rates have increased. However, opioid and non-opioid suicide rates have decreased significantly since 2011, and there have been fewer drug deaths of undetermined intent. Increased attention to the possibility that some suicides are being misclassified is warranted.

摘要

加拿大不断攀升的药物过量死亡率引发了越来越多的关注。为了更好地了解这一健康威胁的程度,我们获取了2000年至2020年的死亡率统计数据和人口数据,并研究了过量死亡的发生率,按照国际疾病分类第十版(ICD - 10)编码为意外、自杀或“意图不明”。被认为对死亡负有主要责任的药物被分类为阿片类、非阿片类或未明确分类。绘制了药物死亡的年龄模式图。采用连接点分析来检验死亡率变化的显著性。自2011年以来,加拿大意外阿片类和兴奋剂过量死亡率攀升得更快,尽管没有美国相应的死亡率高。不明原因的死亡率有所上升。然而,自2011年以来,阿片类和非阿片类自杀率显著下降,意图不明的药物死亡案例也减少了。有必要更加关注一些自杀可能被错误分类的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/66ffa5b65ed2/11469_2022_932_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/a477a00e0fbc/11469_2022_932_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/c1806b14c314/11469_2022_932_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/d60e9b99bb92/11469_2022_932_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/f071d8eaf028/11469_2022_932_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/03d60c2105c0/11469_2022_932_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/dc107085e87d/11469_2022_932_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/e2a998923360/11469_2022_932_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/66ffa5b65ed2/11469_2022_932_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/a477a00e0fbc/11469_2022_932_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/c1806b14c314/11469_2022_932_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/d60e9b99bb92/11469_2022_932_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/f071d8eaf028/11469_2022_932_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/03d60c2105c0/11469_2022_932_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/dc107085e87d/11469_2022_932_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/e2a998923360/11469_2022_932_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c9/9550153/66ffa5b65ed2/11469_2022_932_Fig8_HTML.jpg

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