Song Tiange, Peng Shengkun, Zhou Xiaoli, Jiang Li, Zhang Jie
Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Front Surg. 2022 Sep 29;9:984640. doi: 10.3389/fsurg.2022.984640. eCollection 2022.
Alveolar echinococcosis (AE), caused by larval stages of , is a rare zoonotic disease that mainly involves the liver. The diagnosis of extrahepatic AE is usually difficult. Here, we describe a rare case of vertebral alveolar echinococcosis with a suspected history of spinal tuberculosis, diagnosed by metagenomic next-generation sequencing (mNGS).
A 44-year-old woman presented with repetitive neck and back pain, with a surgical history of suspected spinal tuberculosis. Magnetic resonance imaging (MRI) showed cystic masses in the craniocervical junction region and effusion around lumbar vertebrae. Multiple culture tests were performed to detect tuberculosis and other pathogens through puncture of the effusion and of cerebrospinal fluid, but the results were all negative. Finally, mNGS of the effusion fluid was performed and were detected. The results were further confirmed by Sanger sequencing.
This case emphasizes a role of mNGS in the diagnosis of infectious diseases with unknown pathogen. As a newly emerged sensitive and accurate diagnostic strategy, mNGS provides clinicians an opportunity to clarify pathogens in complicated infectious cases, especially in patients with a history of multiple infections.
泡型包虫病（AE）由多房棘球绦虫的幼虫阶段引起，是一种罕见的人畜共患病，主要累及肝脏。肝外AE的诊断通常很困难。在此，我们描述了一例罕见的脊椎泡型包虫病病例，该病例有疑似脊柱结核病史，通过宏基因组下一代测序（mNGS）确诊。
一名44岁女性因反复出现颈部和背部疼痛就诊，有疑似脊柱结核的手术史。磁共振成像（MRI）显示颅颈交界区有囊性肿块，腰椎周围有积液。通过对积液和脑脊液进行穿刺，进行了多项培养试验以检测结核和其他病原体，但结果均为阴性。最后，对积液进行了mNGS检测，并检测到了[具体内容未给出]。结果通过桑格测序进一步证实。
该病例强调了mNGS在诊断病原体不明的传染病中的作用。作为一种新出现的灵敏且准确的诊断策略，mNGS为临床医生提供了一个在复杂感染病例中明确病原体的机会，尤其是在有多次感染史的患者中。
