长链非编码RNA AP004608.1在前列腺癌中的预后意义
Prognostic significance of lncRNA AP004608.1 in prostate cancer.
作者信息
Li Wei, Zhou Runze, Sun Bo, Jin Xin, Chen Yuan, Xu Xuefen
机构信息
Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Institute of Traditional Chinese medicine (TCM)-Related Comorbid Depression, School of Chinese Medicine & School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
出版信息
Front Oncol. 2022 Sep 29;12:1017635. doi: 10.3389/fonc.2022.1017635. eCollection 2022.
This study aimed to screen and determine the value of AP004608.1 expression as a biomarker for Prostate cancer (PCa) survival. We investigated the expression and prognosis of AP004608.1 through bioinformatics analysis. Low AP004608.1 expression predicted favorable Overall survival (OS) and Progression-free survival (PFS) in PCa patients, according to the Cancer Genome Atlas (TCGA) database. Cox regression demonstrated that low AP004608.1 expression were in-dependent biomarkers for OS. Moreover, Gene Expression Omnibus (GEO) database was utilized to verify the prognostic role of AP004608.1 in PCa, and the similar results were reached. A meta-analysis revealed that low AP004608.1 expression was closely relevant to better OS. AP004608.1 could constitute a promising prognostic biomarker, and probably plays an important role in PCa.
本研究旨在筛选并确定AP004608.1表达作为前列腺癌（PCa）生存生物标志物的价值。我们通过生物信息学分析研究了AP004608.1的表达及预后情况。根据癌症基因组图谱（TCGA）数据库，AP004608.1低表达预示着PCa患者有较好的总生存期（OS）和无进展生存期（PFS）。Cox回归分析表明，AP004608.1低表达是OS的独立生物标志物。此外，利用基因表达综合数据库（GEO）验证AP004608.1在PCa中的预后作用，得出了相似的结果。一项荟萃分析显示，AP004608.1低表达与较好的OS密切相关。AP004608.1可能是一种有前景的预后生物标志物，并且可能在PCa中发挥重要作用。
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