孕期母亲轮班工作与儿童超重及幼儿期代谢结局的关系。
Association between maternal shift work during pregnancy child overweight and metabolic outcomes in early childhood.
机构信息
Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan.
Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
出版信息
Front Public Health. 2022 Sep 30;10:1006332. doi: 10.3389/fpubh.2022.1006332. eCollection 2022.
BACKGROUND
Previous studies found that maternal shift work during pregnancy was associated with many reproductive hazards, including small for gestational age, preterm birth, stillbirth, and neurodevelopmental impairment. Some studies also showed that these children are more likely to become overweight in early childhood. However, the association with metabolic factors, such as insulin resistance and dyslipidemia, was less studied. Hence, we aimed to understand better the relationship between maternal shift work during pregnancy and the risk of childhood overweight and metabolic outcomes. Confounding factors were also discussed, including diet, exercise, and demographical factors.
METHODS
We enrolled pregnant women before delivery in the Taiwan Birth Panel Study (TBPS) II conducted between 2010 and 2012, and followed the children of these participants in 2018. The objective of this study is to investigate the influence of prenatal and postnatal factors on infant and early childhood health. During the follow-up in 2018, we checked children's demographic data, obtained blood specimens, and checked their blood sugar, blood insulin, and lipid profiles. Structured questionnaires were used to evaluate demographic data. Multiple linear and logistic regressions were used to examine the associations between maternal shift work during pregnancy and child overweight, metabolic disorders, such as HOMA-IR, and lipid profiles.
RESULTS
In this study, we included 407 mother-children pairs with different work shifts (350 day workers and 57 shift workers), and a sub-population without underweight children was also created (290 day workers and 47 shift workers). Shift work during pregnancy was associated with a higher Homeostasis Model Assessment-Insulin Resistance index (HOMA-IR) and a higher odds ratio for overweight in children born from mothers doing shift work during pregnancy after adjustment. The findings were attenuated when we investigated the effect of shift work before pregnancy.
CONCLUSION
Our study suggested that maternal shift work during pregnancy was associated with child overweight and insulin resistance in early childhood.
背景
先前的研究发现，孕妇怀孕期间的轮班工作与许多生殖危害有关，包括胎儿生长受限、早产、死产和神经发育障碍。一些研究还表明，这些孩子在幼儿期更容易超重。然而，关于代谢因素的研究较少，如胰岛素抵抗和血脂异常。因此，我们旨在更好地了解孕妇怀孕期间的轮班工作与儿童超重和代谢结果的风险之间的关系。还讨论了混杂因素，包括饮食、运动和人口统计学因素。
方法
我们在 2010 年至 2012 年期间招募了参加台湾生育队列研究（TBPS）II 的孕妇，并在 2018 年对这些参与者的孩子进行了随访。本研究的目的是调查产前和产后因素对婴儿和幼儿健康的影响。在 2018 年的随访中，我们检查了儿童的人口统计学数据，采集了血液样本，并检查了他们的血糖、血胰岛素和血脂谱。使用结构化问卷评估人口统计学数据。多线性和逻辑回归用于检查怀孕期间的母亲轮班工作与儿童超重、代谢紊乱（如 HOMA-IR）和血脂谱之间的关系。
结果
在这项研究中，我们纳入了 407 对母婴对，他们的工作时间不同（350 名日班工人和 57 名轮班工人），并且还创建了一个没有体重不足儿童的亚人群（290 名日班工人和 47 名轮班工人）。调整后，与怀孕期间从事轮班工作的母亲所生的儿童相比，怀孕期间从事轮班工作与更高的稳态模型评估-胰岛素抵抗指数（HOMA-IR）和儿童超重的更高比值有关。当我们调查怀孕前轮班工作的影响时，发现结果减弱。
结论
我们的研究表明，孕妇怀孕期间的轮班工作与儿童在幼儿期超重和胰岛素抵抗有关。
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