Channing Division of Network Medicine, Brigham and Women's Hospital,, Harvard Medical School, Boston, Massachusetts, USA.
Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria.
Obesity (Silver Spring). 2018 Sep;26(9):1491-1500. doi: 10.1002/oby.22267.
This study aimed to investigate associations between maternal history of rotating night shift nursing work before pregnancy and number of night shifts worked during pregnancy with offspring weight outcomes from early life through adolescence.
More than 4,000 children, enrolled in the second phase of the Growing Up Today Study between 2004 and 2013, and their mothers participating in the Nurses' Health Study II were included in our analyses.
Children of women with and without a history of rotating night shift work before pregnancy were similar in birth weight and body size at age 5. However, for mothers with night shift work before pregnancy, their children had a modestly elevated risk of having overweight or obesity (relative risk = 1.11; 95% CI: 1.02-1.21), which was stronger for persistently having overweight or obesity during adolescence and early adulthood. Longer duration of rotating night shift work was not associated with any of these weight outcomes. Weight outcomes of children of women with versus without night shift work during pregnancy were similar, regardless of frequency of night shifts worked during pregnancy (all P > 0.09).
Overall, nurses' night shift work before or during pregnancy did not affect offspring weight outcomes. Future larger studies should explore these associations in more detail.
本研究旨在探讨母亲妊娠前倒班护理工作史和妊娠期间夜班工作次数与后代从婴儿期到青春期体重结局的关系。
本研究纳入了超过 4000 名儿童，他们在 2004 年至 2013 年间参加了第二期“今日成长研究”，其母亲参加了“护士健康研究 II”。
与妊娠前无倒班工作史的母亲相比，有倒班工作史的母亲所生的儿童在出生体重和 5 岁时的体型上没有差异。然而，对于妊娠前有夜班工作史的母亲，其子女超重或肥胖的风险略有增加（相对风险=1.11；95%可信区间：1.02-1.21），在青少年和成年早期持续超重或肥胖的风险更强。倒班工作时间的长短与这些体重结局均无关。无论妊娠期间夜班工作的频率如何，妊娠期间有夜班工作的女性与无夜班工作的女性所生子女的体重结局相似（均 P＞0.09）。
总体而言，护士妊娠前或妊娠期间的夜班工作并未影响后代的体重结局。未来更大规模的研究应更详细地探讨这些关联。
