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光响应性小分子酶模拟物

Photoresponsive Small Molecule Enzyme Mimics.

作者信息

Adak Soumen, Maity Manik Lal, Bandyopadhyay Subhajit

机构信息

Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur, Nadia 741246, West Bengal, India.

出版信息

ACS Omega. 2022 Sep 27;7(40):35361-35370. doi: 10.1021/acsomega.2c05210. eCollection 2022 Oct 11.

DOI:10.1021/acsomega.2c05210
PMID:36249396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9558609/
Abstract

Enzyme mimics emulate the catalytic activities of their natural counterparts. Light-responsive enzyme mimics are an emerging branch of biomimetic chemistry where the catalytic activities can be controlled reversibly by light. These light-responsive systems are constructed by incorporating a suitable photoswitchable unit around the active-site mimic. As these systems are addressable by light, they do not leave back any undesired side products, and their activation-deactivation can be easily controlled. Naturally, these systems have enormous potential in the field of on-demand catalysis. The synthetic light-responsive enzyme mimics are robust and stable under harsh conditions. They do not require special handling protocols like those for real enzymes and can be tailor-made for improved solubility in a variety of solvents. How the introduction of the light-responsive systems has offered a new-edge to the field of small-molecule enzyme mimic has been elaborated in this Mini-review. Recent breakthroughs in light-responsive enzyme-like systems have been highlighted. Finally, the current obstacles and future prospects of this field have been discussed.

摘要

酶模拟物模仿其天然对应物的催化活性。光响应性酶模拟物是仿生化学中一个新兴的分支，其催化活性可以通过光进行可逆控制。这些光响应系统是通过在活性位点模拟物周围引入合适的光开关单元构建而成的。由于这些系统可以通过光进行调控，它们不会留下任何不需要的副产物，并且其激活-失活过程可以很容易地控制。自然而然地，这些系统在按需催化领域具有巨大的潜力。合成的光响应性酶模拟物在苛刻条件下具有很强的稳定性。它们不需要像真实酶那样的特殊处理方案，并且可以进行定制以提高在各种溶剂中的溶解度。本综述阐述了光响应系统的引入如何为小分子酶模拟物领域带来了新的优势。文中强调了光响应性类酶系统的最新突破。最后，讨论了该领域当前的障碍和未来前景。

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