Campbell J H, Campbell G R, Kocher O, Gabbiani G
Int Angiol. 1987 Jan-Mar;6(1):73-9.
Smooth muscle cells are one of the most important, if not the most important component of atheromatous plaque. Smooth muscle cells from developing and regenerating arteries, as well as atheromatous plaques, show similar morphological and biochemical characteristics which differ from adult tissue. During primary culture, adult smooth muscle cells alter their morphology to resemble those of the developing, regenerating and atheromatous material. We propose that primary cell culture of smooth muscle cells provides a model for the study of smooth muscle cell changes during atheroma formation.
平滑肌细胞即便不是动脉粥样硬化斑块最重要的组成部分，也是其最重要的组成部分之一。来自发育中和再生动脉以及动脉粥样硬化斑块的平滑肌细胞表现出与成年组织不同的相似形态学和生化特征。在原代培养过程中，成年平滑肌细胞会改变其形态，使其类似于发育中的、再生的和动脉粥样硬化组织中的平滑肌细胞。我们认为，平滑肌细胞的原代细胞培养为研究动脉粥样硬化形成过程中平滑肌细胞的变化提供了一个模型。
