Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Social Determinants of Health Research Center, Department of Epidemiology and Biostatistics, Faculty of Health, Birjand University of Medical Sciences, Birjand, Iran.
Trans R Soc Trop Med Hyg. 2018 Dec 1;112(12):529-537. doi: 10.1093/trstmh/try094.
We performed a systematic review and meta-analysis on observational studies to evaluate the possible associations between Toxocara species seropositivity and allergic skin disorders (ASDs). We searched the MEDLINE, ScienceDirect, Scopus, Web of Science and Google Scholar databases to 15 May 2018 to identify the relevant studies. We used a random effects meta-analysis model to generate the pooled odds ratio (OR) and 95% confidence intervals (CIs). Fifteen studies, including eight studies with a case-control design (735 patients and 1342 controls) and seven studies with a cross-sectional design (a total of 4804 participants, 1302 individuals with ASDs and 3502 without ASDs), were included in the meta-analysis. We found an increased risk for ASDs in individuals with Toxocara seropositivity (OR 1.75 [95% CI 1.16 to 2.64]). Subanalysis showed that Toxocara seropositivity was significantly associated with urticaria (OR 2.97 [95% CI 1.53 to 5.76]), however, it was not significantly associated with atopy (OR 1.08 [95% CI 0.55 to 2.15]) and eczema (OR 1.62 [95% CI 0.95 to 2.78]). Moreover, the pooled ORs were 2.34 (95% CI 1.32 to 4.15) and 1.27 (95% CI 0.69 to 2.35) for case-control and cross-sectional studies, respectively. The results of our study support hypotheses regarding the existence of a positive relationship between Toxocara infection and allergic disorders, although this association should be further investigated by longitudinal and mechanism studies.
我们进行了一项系统评价和荟萃分析，评估了旋毛虫物种血清阳性与过敏性皮肤疾病（ASD）之间可能存在的关联。我们检索了 MEDLINE、ScienceDirect、Scopus、Web of Science 和 Google Scholar 数据库，截至 2018 年 5 月 15 日，以确定相关研究。我们使用随机效应荟萃分析模型生成汇总比值比（OR）和 95%置信区间（CI）。共纳入 15 项研究，包括 8 项病例对照设计的研究（735 例患者和 1342 例对照）和 7 项横断面设计的研究（共 4804 名参与者，1302 名 ASD 患者和 3502 名无 ASD 患者）。我们发现，旋毛虫血清阳性者患 ASD 的风险增加（OR 1.75 [95% CI 1.16 至 2.64]）。亚组分析显示，旋毛虫血清阳性与荨麻疹显著相关（OR 2.97 [95% CI 1.53 至 5.76]），但与特应性（OR 1.08 [95% CI 0.55 至 2.15]）和湿疹（OR 1.62 [95% CI 0.95 至 2.78]）无显著相关性。此外，病例对照研究和横断面研究的汇总 OR 分别为 2.34（95% CI 1.32 至 4.15）和 1.27（95% CI 0.69 至 2.35）。我们的研究结果支持旋毛虫感染与过敏性疾病之间存在正相关关系的假设，尽管这一关联应通过纵向和机制研究进一步探讨。
