基因组报告：雪豹、非洲豹和老虎（雪豹、非洲豹和孟加拉虎）的染色体水平草图组装。

Department of Biology, Stanford University, Stanford, CA 94305, USA.

Department of Biology, Washington State University, Pullman, WA 99164, USA.

G3 (Bethesda). 2022 Dec 1;12(12). doi: 10.1093/g3journal/jkac277.

The big cats (genus Panthera) represent some of the most popular and charismatic species on the planet. Although some reference genomes are available for this clade, few are at the chromosome level, inhibiting high-resolution genomic studies. We assembled genomes from 3 members of the genus, the tiger (Panthera tigris), the snow leopard (Panthera uncia), and the African leopard (Panthera pardus pardus), at chromosome or near-chromosome level. We used a combination of short- and long-read technologies, as well as proximity ligation data from Hi-C technology, to achieve high continuity and contiguity for each individual. We hope that these genomes will aid in further evolutionary and conservation research of this iconic group of mammals.

大型猫科动物（属 Panthera）是地球上最受欢迎和最具魅力的物种之一。虽然这个进化枝有一些参考基因组，但很少有达到染色体水平的，这阻碍了高分辨率基因组研究。我们组装了 3 个属成员的基因组，即老虎（Panthera tigris）、雪豹（Panthera uncia）和非洲豹（Panthera pardus pardus），达到了染色体或接近染色体的水平。我们结合使用了短读长和长读长技术，以及 Hi-C 技术的邻近连接数据，以实现每个个体的高连续性和连续性。我们希望这些基因组将有助于进一步研究这一标志性哺乳动物群体的进化和保护。