绝经前期和早期的身体功能与心血管事件风险：全国妇女健康研究。
Pre- and Early Peri-menopausal Physical Function and Risk of Cardiovascular Events: The Study of Women's Health Across the Nation.
机构信息
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Department of Family and Preventive Medicine, Rush University Medical Center, Chicago, IL, USA.
出版信息
J Aging Health. 2023 Jun;35(5-6):383-391. doi: 10.1177/08982643221133580. Epub 2022 Oct 17.
OBJECTIVES
To determine whether physical function (PF) before menopause is related to cardiovascular disease (CVD) risk.
METHODS
Participants were = 2950 pre-/early peri-menopausal women (median age 46, (25th-75th percentile: 43-48 years). Physical function was assessed at baseline using the Physical Function subscale of the SF-36 and scores were trichotomized (no, some, or substantial limitations). Clinical CVD events were ascertained at annual/biennial clinical assessments through the 15th follow-up visit. Risk of CVD was determined with Cox proportional hazards models. Women were followed for a median of 19.1 years, during which 220 women had a CVD event. In fully adjusted models, women with substantial limitations at baseline had higher CVD risk compared to women with no limitations (hazards ratio [HR] = 1.55, 95% confidence interval [CI]: 1.12-2.33). Substantial PF limitations in pre- and early peri-menopausal women are associated with higher risk of clinical CVD events, consistent with literature in older adults.
目的
确定绝经前的身体功能是否与心血管疾病（CVD）风险相关。
方法
参与者为 2950 名绝经前期/早期的女性（中位年龄 46 岁，（25 百分位数-75 百分位数：43-48 岁）。在基线时使用 SF-36 的身体功能子量表评估身体功能，评分分为三部分（无、有些、严重受限）。通过第 15 次随访期间的年度/两年期临床评估确定临床 CVD 事件。使用 Cox 比例风险模型确定 CVD 风险。女性中位随访 19.1 年，在此期间 220 名女性发生 CVD 事件。在完全调整的模型中，与无限制的女性相比，基线时存在严重限制的女性发生 CVD 的风险更高（风险比 [HR] = 1.55，95%置信区间 [CI]：1.12-2.33）。绝经前期和早期的女性存在严重的 PF 限制，与临床 CVD 事件风险增加相关，这与老年人的文献一致。
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