Vidal-Gomez J, Hammarströme L, Smith C I
Scand J Immunol. 1978;8(4):313-21. doi: 10.1111/j.1365-3083.1978.tb00524.x.
In an attempt to definitively determine whether the pure presentation of haptens (on repetitive, non-metabolizable carriers) to B lymphocytes triggers differentiation to antibody-producing cells, dinitrophenyl and trinitrophenyl groups have been covalently coupled to potentially inert carriers (polymethylmethacrylate, chlorinated polyethylene and cellulose). The resulting conjugates (with three different degrees of hapten substitution) are not immunogenic. It is therefore concluded that the pure presentation of haptens to B lymphocytes does not trigger antibody formation.
为了明确确定半抗原（连接在重复性、不可代谢载体上）单纯呈现给B淋巴细胞是否会触发其分化为抗体产生细胞，已将二硝基苯基和三硝基苯基共价偶联到潜在惰性载体（聚甲基丙烯酸甲酯、氯化聚乙烯和纤维素）上。所得到的结合物（具有三种不同程度的半抗原取代）不具有免疫原性。因此得出结论，半抗原单纯呈现给B淋巴细胞不会触发抗体形成。
