Cohn S L, Herst C V, Maurer H S, Rosen S T
J Clin Oncol. 1987 Sep;5(9):1441-4. doi: 10.1200/JCO.1987.5.9.1441.
N-myc amplification is most frequently found in neuroblastoma from patients with stage III and IV disease. Recently a significant association between genomic amplification and poor prognosis has been demonstrated. The primary tumors studied from patients with stage IVS disease have reportedly had a single copy of N-myc, and these patients are alive without progressive disease. We report a patient with stage IVS neuroblastoma with N-myc amplification who developed widespread metastasis within 6 months of diagnosis. The same correlation between oncogene copy number and progressive disease that has been seen in those patients with stage II, III, and IV disease was seen in this patient with stage IVS neuroblastoma.
N-myc扩增最常见于患有III期和IV期疾病的神经母细胞瘤患者中。最近已证实基因组扩增与预后不良之间存在显著关联。据报道，患有IVS期疾病患者的原发性肿瘤有一个N-myc拷贝，且这些患者存活且无疾病进展。我们报告了一名患有IVS期神经母细胞瘤且伴有N-myc扩增的患者，该患者在诊断后6个月内发生了广泛转移。在这名患有IVS期神经母细胞瘤的患者中，观察到与患有II期、III期和IV期疾病的患者中相同的癌基因拷贝数与疾病进展之间的相关性。
