正常和病变角膜中的自噬作用。
Autophagy in the normal and diseased cornea.
机构信息
Department of Cell Biology, University of Virginia, Charlottesville, VA, USA.
Department of Cell Biology, University of Virginia, Charlottesville, VA, USA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA.
出版信息
Exp Eye Res. 2022 Dec;225:109274. doi: 10.1016/j.exer.2022.109274. Epub 2022 Oct 14.
The cornea and covering tear film are together the 'objective lens' of the eye through which 80% of light is refracted. Despite exposure to a physically harsh and at times infectious or toxic environment, transparency essential for sight is in most cases maintained. Such resiliency makes the avascular cornea a superb model for the exploration of autophagy in the regulation of homeostasis with relevancy to all organs. Nonetheless, missense mutations and inflammation respectively clog or apparently overwhelm autophagic flux to create dystrophies much like in neurodegenerative diseases or further exacerbate inflammation. Here there is opportunity to generate novel topical therapies towards the restoration of homeostasis with potential broad application.
角膜和覆盖的泪膜共同构成了眼睛的“物镜”，80%的光线通过它折射。尽管暴露在物理上恶劣的环境中，有时还会受到感染或有毒物质的影响，但眼睛保持透明对于视力是至关重要的。这种弹性使得角膜成为研究自噬在维持体内平衡中的作用的极佳模型，与所有器官都相关。尽管如此，错义突变和炎症分别通过堵塞或明显压倒自噬流来导致营养不良，就像神经退行性疾病一样，或者进一步加剧炎症。这里有机会产生新的局部治疗方法，以恢复体内平衡，并具有广泛的潜在应用。
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