Cha C J, Gelardi N L, Oh W
J Nutr. 1987 Aug;117(8):1463-8. doi: 10.1093/jn/117.8.1463.
We evaluated the catch-up growth of rats with intrauterine growth retardation (IUGR) raised in normal litters (8-10 pups) or in large litters (14-16 pups) during the first 2 wk of life. We also studied the influence of nutrition on cellular composition at birth and at 2 wk. Fifty-four pups (27 IUGR and 27 controls) were enrolled into normal or undernutrition groups. Postnatal undernutrition resulted in significantly lower growth in both control and IUGR rat pups than in normally fed pups. In the control group, postnatal undernutrition resulted in a lower liver weight but not a lower brain weight. Underfeeding of the IUGR group produced a greater number of cells of the brain and liver, but with smaller cell size than in normally fed IUGR rats. We conclude that compensatory catch-up growth in the mild-IUGR rat occurs if the postnatal nutrition is adequate. When postnatal nutrition is restricted, the non-IUGR rats became malnourished at 2 wk of age and the mild-IUGR rats did not demonstrate the catch-up growth phenomenon as was seen in those with adequate nutrition. In the severe-IUGR rat, undernutrition further compromised growth rate, so that at 2 wk of age their weights were the lowest of all the groups studied.
我们评估了出生后前2周生活在正常窝仔数（8 - 10只幼崽）或大窝仔数（14 - 16只幼崽）中的宫内生长受限（IUGR）大鼠的追赶生长情况。我们还研究了营养对出生时及2周龄时细胞组成的影响。54只幼崽（27只IUGR幼崽和27只对照幼崽）被纳入正常或营养不良组。出生后营养不良导致对照和IUGR大鼠幼崽的生长均显著低于正常喂养的幼崽。在对照组中，出生后营养不良导致肝脏重量降低，但脑重量未降低。IUGR组喂养不足导致脑和肝脏中的细胞数量增多，但细胞大小比正常喂养的IUGR大鼠小。我们得出结论，如果出生后营养充足，轻度IUGR大鼠会出现代偿性追赶生长。当出生后营养受限，非IUGR大鼠在2周龄时会出现营养不良，而轻度IUGR大鼠未表现出在营养充足的大鼠中所见的追赶生长现象。在重度IUGR大鼠中，营养不良进一步损害生长速度，以至于在2周龄时它们的体重是所有研究组中最低的。
