Tsuji Masahiro, Tanaka Nao, Koike Hitomi, Sato Yoshiaki, Shimoyama Yoshie, Itoh Ayaka
Department of Food and Nutrition, Kyoto Women's University, Kyoto 605-8501, Japan.
Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya 466-8560, Japan.
Life (Basel). 2023 Oct 2;13(10):2005. doi: 10.3390/life13102005.
Children with fetal growth restriction (FGR) and its resultant low birthweight (LBW) are at a higher risk of developing various health problems later in life, including renal diseases, metabolic syndrome, and sarcopenia. The mechanism through which LBW caused by intrauterine hypoperfusion leads to these health problems has not been properly investigated. Oral supplementation with probiotics is expected to reduce these risks in children. In the present study, rat pups born with FGR-LBW after mild intrauterine hypoperfusion were supplemented with either Bifidobacterium breve () or a vehicle from postnatal day 1 (P1) to P21. Splanchnic organs and skeletal muscles were evaluated at six weeks of age. Compared with the sham group, the LBW-vehicle group presented significant changes as follows: overgrowth from infancy to childhood; lighter weight of the liver, kidneys, and gastrocnemius and plantaris muscles; reduced height of villi in the ileum; and increased depth of crypts in the jejunum. Some of these changes were milder in the LBW-B.breve group. In conclusion, this rat model could be useful for investigating the mechanisms of how FGR-LBW leads to future health problems and for developing interventions for these problems. Supplementation with in early life may modestly attenuate these problems.
患有胎儿生长受限（FGR）及其导致的低出生体重（LBW）的儿童在日后生活中患各种健康问题的风险更高，包括肾脏疾病、代谢综合征和肌肉减少症。宫内灌注不足导致的低出生体重引发这些健康问题的机制尚未得到充分研究。口服补充益生菌有望降低儿童出现这些风险的可能性。在本研究中，轻度宫内灌注不足后出生的FGR-LBW幼鼠从出生后第1天（P1）至第21天补充短双歧杆菌（Bifidobacterium breve）或赋形剂。在六周龄时评估内脏器官和骨骼肌。与假手术组相比，LBW-赋形剂组出现了以下显著变化：从婴儿期到儿童期过度生长；肝脏、肾脏以及腓肠肌和跖肌重量减轻；回肠绒毛高度降低；空肠隐窝深度增加。其中一些变化在LBW-B.breve组中较轻。总之，该大鼠模型可用于研究FGR-LBW导致未来健康问题的机制，并开发针对这些问题的干预措施。在生命早期补充短双歧杆菌可能会适度减轻这些问题。
