Garofano A, Czernichow P, Bréant B
INSERM U457, Hôpital Robert-Debré, Paris, France.
Biol Neonate. 1998;73(2):89-98. doi: 10.1159/000013964.
A rat model of perinatal malnutrition was designed to study the role of nutrition in postnatal somatic growth and insulin stores until adulthood. Maternal food restriction (50%) from day 15 of pregnancy resulted in intrauterine growth retardation (IUGR) in the offspring. The outcome of moderate or severe IUGR was investigated. Neonates with moderate IUGR normally nourished postnatally showed normal body and organ weights and normal insulin contents in adulthood. Offspring with severe IUGR normally nourished postnatally also rapidly recovered normal body and pancreatic weights, but liver and kidney weights were significantly reduced at adult age. Malnutrition until weaning in offspring with severe IUGR induced marked growth retardation (50%) in body and organ weights at weaning. Although pancreatic weight recovered at adult age, body, liver and kidney weights were irreversibly affected, despite several months of normal nutrition. Furthermore, severe IUGR at birth resulted in decreased insulin content at adult age, irrespective of postnatal nutrition. In conclusion, this animal model demonstrates that normalization of adult size can be dissociated from organ growth and also that altered insulin stores in adulthood are more dependent on the severity of IUGR at birth than on postnatal catch-up in organ growth.
设计了一种围产期营养不良的大鼠模型，以研究营养在出生后直至成年期的躯体生长和胰岛素储备中的作用。从怀孕第15天开始对母体进行50%的食物限制，导致后代出现宫内生长迟缓（IUGR）。研究了中度或重度IUGR的结果。出生后正常喂养的中度IUGR新生儿在成年期表现出正常的身体和器官重量以及正常的胰岛素含量。出生后正常喂养的重度IUGR后代也能迅速恢复正常的身体和胰腺重量，但成年时肝脏和肾脏重量显著降低。重度IUGR后代断奶前的营养不良导致断奶时身体和器官重量明显生长迟缓（50%）。尽管成年时胰腺重量恢复了，但身体、肝脏和肾脏重量受到了不可逆的影响，尽管随后有几个月的正常营养。此外，出生时的重度IUGR导致成年时胰岛素含量降低，与出生后的营养状况无关。总之，这个动物模型表明，成年大小的正常化可以与器官生长分离，而且成年期胰岛素储备的改变更多地取决于出生时IUGR的严重程度，而不是出生后器官生长的追赶情况。
