Frazier O H, Colon R, Taenaka Y, Igo S, Fuqua J
J Heart Transplant. 1986 Jul-Aug;5(4):286-90.
Early clinical experience with total artificial hearts has stimulated further research and interest in this field. The concept of total heart replacement with a permanent mechanical device has been reevaluated, and its application as a bridge to heart transplantation is becoming more widely accepted. The size of total artificial hearts, however, limits the number of cases in which they can be used. In an effort to solve this problem, we evaluated a single-ventricle artificial pump in six Hereford calves. During surgery, the left ventricle was excised and replaced with a pneumatically actuated polyurethane pump connected to the mitral and aortic valve anulus. The right ventricle provided flow through the pulmonary vasculature, which eliminated the necessity of maintaining elevated right-sided filling pressures. The single-ventricle pump required less space than a biventricular device and was capable of maintaining adequate hemodynamic parameters in experimental animals. In comparison with the biventricular pump, this device offered the advantages of less extensive dissection requirements, ease of anastomosis, and a better anatomic fit. Patients whose pericardial cavities are too small for a biventricular artificial heart may benefit from the single-ventricle pump if they require hemodynamic support while awaiting heart transplantation.
全人工心脏的早期临床经验激发了该领域的进一步研究和兴趣。用永久性机械装置进行全心脏置换的概念已被重新评估，其作为心脏移植桥梁的应用正越来越被广泛接受。然而，全人工心脏的尺寸限制了其可使用的病例数量。为了解决这个问题，我们在六头赫里福德小牛身上评估了一种单心室人工泵。手术过程中，切除左心室并用一个连接到二尖瓣和主动脉瓣环的气动聚氨酯泵进行替换。右心室提供通过肺血管系统的血流，从而消除了维持右侧高充盈压的必要性。单心室泵比双心室装置所需空间更小，并且能够在实验动物中维持足够的血流动力学参数。与双心室泵相比，该装置具有解剖分离范围小、吻合容易和解剖贴合更好等优点。对于那些心包腔过小无法容纳双心室人工心脏的患者，如果他们在等待心脏移植期间需要血流动力学支持，可能会从单心室泵中受益。
