影响腹腔镜子宫肌瘤切除术手术结局的因素。一项倾向评分匹配分析。
Factors influencing surgical outcomes of laparoscopic myomectomy. A propensity-score matched analysis.
作者信息
Catanese Amedeo, Siesto Gabriele, Cucinella Gaspare, Chiantera Vito, Culmone Silvia, Schiattarella Antonio, Calagna Gloria, Vitobello Domenico
机构信息
Obstetrics and Gynecology, "Umberto I" Hospital - ASP 8, Siracusa, Italy.
Obstetrics and Gynecology, Humanitas Clinical and Research Center, Rozzano (MI), Italy.
出版信息
Prz Menopauzalny. 2022 Sep;21(3):149-156. doi: 10.5114/pm.2022.118970. Epub 2022 Sep 1.
INTRODUCTION
To evaluate factors influencing surgical choice in performing uterine myomectomy by comparing laparoscopic and open approach surgery.
MATERIAL AND METHODS
We analyzed women undergoing uterine myomectomy in our hospital. Patients were divided into two groups: patients who underwent laparoscopic myomectomy (group A) and patients who underwent laparotomic myomectomy (group B). We matched 1 : 1 women in these two groups to compare the effects of the procedures on each outcome according to a propensity-matched score analysis.
RESULTS
460 myomectomies were performed in the study period: 361 cases by laparoscopy (group A) and 99 cases by laparotomy (group B). We found lower estimated intraoperative blood loss (200 ml group A vs. 300 ml group B, < 0.0001) and a smaller decrease in hemoglobin value on the first postoperative day (1.7 g/dl group A vs. 2.2 g/dl group B, < 0.0001) with the laparoscopic approach. The propensity score matching estimated that to obtain an equivalent outcome, we required an average of 2 myomas and an average diameter of 8 cm in laparoscopy and 10 cm in laparotomy. Moreover, the variables mostly associated with a laparotomic conversion were the presence of a myoma > 8 cm and association with the presence of more than 2 myomas.
CONCLUSIONS
Despite some proposals from previous studies, there are no specific guidelines regarding the best surgical procedure for myomectomy. Our data confirm that the choice of surgical technique should consider the patient characteristics and the surgeon experience to reduce longer operating times and more significant blood loss.
引言
通过比较腹腔镜手术和开放手术,评估影响子宫肌瘤切除术手术方式选择的因素。
材料与方法
我们分析了在我院接受子宫肌瘤切除术的女性患者。患者分为两组:接受腹腔镜子宫肌瘤切除术的患者(A组)和接受开腹子宫肌瘤切除术的患者(B组)。根据倾向得分匹配分析,将这两组患者按1:1进行匹配,以比较两种手术方式对各项结局的影响。
结果
在研究期间共进行了460例子宫肌瘤切除术:腹腔镜手术361例(A组),开腹手术99例(B组)。我们发现,腹腔镜手术组的估计术中失血量较低(A组200 ml vs. B组300 ml,<0.0001),术后第一天血红蛋白值下降幅度较小(A组1.7 g/dl vs. B组2.2 g/dl,<0.0001)。倾向得分匹配估计,为获得等效结局,腹腔镜手术平均需要2个肌瘤,平均直径8 cm,开腹手术平均直径10 cm。此外,与转为开腹手术最相关的变量是存在直径>8 cm的肌瘤以及伴有2个以上肌瘤。
结论
尽管先前的研究提出了一些建议,但对于子宫肌瘤切除术的最佳手术方式尚无具体指南。我们的数据证实,手术技术的选择应考虑患者特征和外科医生经验,以减少手术时间延长和失血过多的情况。