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探索子宫肌瘤治疗的手术策略:对开放和微创方法文献的综合回顾。

Exploring Surgical Strategies for Uterine Fibroid Treatment: A Comprehensive Review of Literature on Open and Minimally Invasive Approaches.

机构信息

Unit of Gynecology and Obstetrics, Department of Human Pathology of Adult and Childhood "G. Barresi", University of Messina, 98122 Messina, Italy.

Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

出版信息

Medicina (Kaunas). 2023 Dec 28;60(1):64. doi: 10.3390/medicina60010064.

Abstract

Uterine myomas represent one of the most prevalent pathologies affecting the female population. These benign neoplasms originate from the smooth muscular cells of the uterus, and they can be either single or multiple. Often associated with debilitating symptoms such as pelvic heaviness, pain, constipation, and urinary dysfunctions, the surgical management of myomectomy exhibits considerable variability. This diversity in approaches is influenced by factors such as the number and size of myomas, the patient's age, and overall clinical conditions. This study aims to elucidate and compare the advantages and disadvantages of different surgical approaches, specifically endoscopic procedures versus open surgery, providing valuable insights for clinical decision making. A comprehensive bibliographic search spanning from 2013 to 2023 was systematically conducted across databases including Medline, Embase, the Cochrane Database of Systematic Reviews, and ClinicalTrials.gov. The search utilized keywords such as "myomectomy laparoscopic and open", "myomectomy open and minimally invasive", "myomectomy open and laparoscopic", and "myomectomy open vs. laparoscopic." The research methodology, along with predetermined inclusion and exclusion criteria, was established prior to the search, ensuring a systematic and rigorous approach. Subsequently, data analysis was carried out. Following the study selection process, 25 articles met the eligibility criteria for inclusion in this analysis. The average numbers of myomas were 3.7 (ranging from 1 to 13.7) and 5.4 (ranging from 1 to 13.5) for the minimally invasive surgery and open surgery groups, respectively. In terms of myoma size, the total averages across studies were 7 cm (ranging from 4.8 to 14) for the minimally invasive group and 8 cm (ranging from 3.9 to 11.2) for the open surgery group. The average pregnancy and delivery rates were 29.7% (ranging from 1.8 to 100) for the minimally invasive group and 28.5% (ranging from 1.8 to 100) for the open surgery group. Regarding complications, the average rate was 14.2% (ranging from 0 to 50) for the endoscopic group and 22.3% (ranging from 0 to 60.3) for the laparotomic group. In conclusion, a critical factor influencing the choice of surgical approach is primarily the size and quantity of fibroids. The mini-laparotomic approach emerges as a viable alternative to endoscopy, demonstrating favorable surgical outcomes and aesthetic results. Interestingly, the type of surgical procedure appears to have no significant impact on the pregnancy rate.

摘要

子宫肌瘤是影响女性人群最常见的病症之一。这些良性肿瘤起源于子宫的平滑肌细胞,可以是单发或多发。常伴有盆腔沉重感、疼痛、便秘和尿功能障碍等使人虚弱的症状,子宫肌瘤切除术的手术管理存在相当大的变异性。这种方法的多样性受到许多因素的影响,如肌瘤的数量和大小、患者的年龄和整体临床状况。本研究旨在阐明和比较不同手术方法的优缺点,特别是内镜手术与开放手术,为临床决策提供有价值的见解。

从 2013 年到 2023 年,我们系统地在 Medline、Embase、Cochrane 系统评价数据库和 ClinicalTrials.gov 等数据库中进行了全面的文献检索。搜索使用了“腹腔镜和开腹子宫肌瘤切除术”、“开腹和微创手术子宫肌瘤切除术”、“开腹和腹腔镜子宫肌瘤切除术”和“开腹与腹腔镜子宫肌瘤切除术”等关键词。研究方法以及预定的纳入和排除标准在搜索前建立,以确保系统和严格的方法。随后进行了数据分析。

在研究选择过程之后,有 25 篇文章符合纳入本分析的标准。微创手术组和开放手术组的平均肌瘤数分别为 3.7(范围为 1 至 13.7)和 5.4(范围为 1 至 13.5)。就肌瘤大小而言,各研究的总平均值为 7cm(范围为 4.8 至 14),微创手术组为 8cm(范围为 3.9 至 11.2)。开放手术组。微创组的平均妊娠和分娩率为 29.7%(范围为 1.8%至 100%),开放手术组为 28.5%(范围为 1.8%至 100%)。关于并发症,内镜组的平均发生率为 14.2%(范围为 0 至 50%),剖腹组为 22.3%(范围为 0 至 60.3%)。

总之,影响手术方式选择的一个关键因素主要是肌瘤的大小和数量。迷你剖腹手术方法作为内镜手术的一种可行替代方法,显示出良好的手术效果和美容效果。有趣的是,手术类型似乎对妊娠率没有显著影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c027/10820219/bc4e5f10ac60/medicina-60-00064-g001.jpg

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