Morávek J, Schück O, Hatala M, Príborský J
J Pharmacokinet Biopharm. 1987 Feb;15(1):15-23. doi: 10.1007/BF01062936.
The rates of total and extrarenal elimination of amikacin, cefoperazone, ceftriaxone, gentamicin, mesocain, theophylline, tobramycin, and polyfructosane-S were determined in rats with intact kidneys and in those after bilateral nephrectomy. While the values of the elimination constants of the tested drugs were markedly higher in the rats than in man, the ratio of nonrenal and total elimination constants, expressing the fraction of drugs eliminated extrarenally, is close to the value found in man. These findings suggest that the model might be useful in preclinical drug testing and can help in the prediction of changes in the kinetics of drugs caused by renal failure.
在肾脏完好的大鼠以及双侧肾切除后的大鼠中，测定了阿米卡星、头孢哌酮、头孢曲松、庆大霉素、美索卡因、茶碱、妥布霉素和聚果糖酐 -S的总消除率和肾外消除率。虽然受试药物在大鼠中的消除常数数值明显高于人类，但非肾消除常数与总消除常数的比值（表示肾外消除的药物分数）与在人类中发现的值接近。这些发现表明，该模型可能在临床前药物测试中有用，并且有助于预测肾衰竭引起的药物动力学变化。
