Morávek J, Schück O, Hatala M, Príborský J
Czech Med. 1986;9(3):153-6.
Elimination of gentamicin, tobramycin, amikacin, cefoperazone, ceftriaxon and lithium was investigated in healthy and bilaterally nephrectomized rats. This model of renal failure was used to determine the nonrenal elimination constantsebz, diesambino calculation of the ratio of the nonrenal and total elimination constant Qo. The values of Qo of the investigated drugs in the used model were very close to those given in the literature for men. These results suggest that the described model can be helpful in predicting the percentage of drug excreted renally and nonrenally, and the delay in drug excretion in renal insufficiency.
在健康大鼠和双侧肾切除的大鼠中研究了庆大霉素、妥布霉素、阿米卡星、头孢哌酮、头孢曲松和锂的消除情况。使用这种肾衰竭模型来确定非肾消除常数ebz，通过双室模型计算非肾消除常数与总消除常数的比值Qo。在所使用的模型中，所研究药物的Qo值与文献中给出的男性的值非常接近。这些结果表明，所描述的模型有助于预测药物经肾和非肾排泄的百分比，以及肾衰竭时药物排泄的延迟情况。
