Changes of pharmacokinetic in rats after bilateral nephrectomy--a model for prediction of pharmacokinetic changes in patients with chronic renal insufficiency.

Elimination of gentamicin, tobramycin, amikacin, cefoperazone, ceftriaxon and lithium was investigated in healthy and bilaterally nephrectomized rats. This model of renal failure was used to determine the nonrenal elimination constantsebz, diesambino calculation of the ratio of the nonrenal and total elimination constant Qo. The values of Qo of the investigated drugs in the used model were very close to those given in the literature for men. These results suggest that the described model can be helpful in predicting the percentage of drug excreted renally and nonrenally, and the delay in drug excretion in renal insufficiency.