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酒精滥用药物双硫仑对溶组织内阿米巴寄生虫的囊前期有效。

Alcohol Abuse Drug Disulfiram Is Effective against Cyst Stages of Entamoeba histolytica Parasite.

机构信息

Division of Infectious Diseases & International Health, Department of Medicine, University of Virginiagrid.27755.32, Charlottesville, Virginia, USA.

出版信息

Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0083222. doi: 10.1128/aac.00832-22. Epub 2022 Oct 18.

DOI:10.1128/aac.00832-22
PMID:36255253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9664845/
Abstract

New anti-Entamoeba histolytica multistage drugs are needed because only one drug class, nitroimidazoles, is available for treating invasive disease, and it does not effectively eradicate the infective cyst stage. Zinc ditiocarb (ZnDTC), a main metabolite of the FDA-approved drug disulfiram, was recently shown to be highly effective against the invasive trophozoite stage. In this brief report, we show that ZnDTC is active against cysts, with similar potency to first-line cysticidal drug paromomycin.

摘要

需要新的抗溶组织内阿米巴多阶段药物，因为目前仅有一类药物，即硝基咪唑类，可用于治疗侵袭性疾病，而且不能有效消除感染性囊型阶段。锌二硫代氨基甲酸盐（ZnDTC）是美国食品和药物管理局批准的药物双硫仑的主要代谢物，最近被证明对侵袭性滋养体阶段非常有效。在本简要报告中，我们表明 ZnDTC 对囊型阶段具有活性，与一线囊虫药物巴龙霉素的效力相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a791/9664845/9b07c106ac01/aac.00832-22-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a791/9664845/620e10d76402/aac.00832-22-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a791/9664845/9b07c106ac01/aac.00832-22-f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a791/9664845/620e10d76402/aac.00832-22-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a791/9664845/9b07c106ac01/aac.00832-22-f002.jpg

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本文引用的文献

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Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0120721. doi: 10.1128/AAC.01207-21. Epub 2021 Dec 6.
2
Encystation of in Axenic Culture.在无菌培养中包囊化。 （注：原文中“Encystation of in Axenic Culture.”表述似乎不完整，“of”后面缺少具体内容，这里是按照字面意思翻译的。）
Microorganisms. 2021 Apr 18;9(4):873. doi: 10.3390/microorganisms9040873.
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Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box.从 MMV 大流行应对盒的开源资源中发现的多阶段和传播阻断靶向抗疟药物。
Nat Commun. 2021 Jan 11;12(1):269. doi: 10.1038/s41467-020-20629-8.
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Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae.发现可再利用药物候选物用于治疗由致病性自由生活阿米巴引起的疾病。
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