Ghosh Swagata, Padalia Jay, Moonah Shannon
1Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA USA.
2Division of Infectious Diseases, Department of Medicine, University of Virginia Health System, 345 Crispell Drive, MR-6 1st floor, Room 1709, Charlottesville, VA 22908 USA.
Curr Clin Microbiol Rep. 2019;6(1):51-57. doi: 10.1007/s40588-019-0113-6. Epub 2019 Jan 21.
is a protozoan parasite that causes amebiasis, which remains a significant cause of morbidity and mortality worldwide. causes tissue destruction which leads to clinical disease. This review outlines some of the recent advances that have furthered our understanding of the processes that lead to the tissue damage caused by
Recent studies have identified new mechanisms involved in -induced tissue damage. These include (i) new form of contact-dependent killing called trogocytosis; (ii) parasite-produced cytokine, macrophage migration inhibitory factor, that contributes to inflammation; (iii) exploitation of host immune response to promote invasion; and (iv) the contribution of the gut microbiome to clinical disease.
Targeting these mechanisms that result in tissue injury should be a focus of future research for the development of improved preventive and therapeutic strategies for amebiasis.
是一种导致阿米巴病的原生动物寄生虫，在全球范围内仍是发病和死亡的重要原因。会导致组织破坏，进而引发临床疾病。本综述概述了一些最新进展，这些进展进一步加深了我们对导致由引起的组织损伤过程的理解。
最近的研究确定了参与诱导组织损伤的新机制。这些机制包括：（i）一种称为胞啃作用的新型接触依赖性杀伤形式；（ii）寄生虫产生的细胞因子巨噬细胞迁移抑制因子，其有助于炎症反应；（iii）利用宿主免疫反应促进侵袭；以及（iv）肠道微生物群对临床疾病的影响。
针对这些导致组织损伤的机制，应成为未来研究的重点，以开发改进的阿米巴病预防和治疗策略。
