de Fougerolles A R, Baines M G
J Reprod Immunol. 1987 Jun;11(2):147-53. doi: 10.1016/0165-0378(87)90018-0.
Effector cells associated with an aborting fetus appear to be both thymus derived (T) and natural killer (NK) cells. In order to test the hypothesis that NK cells are a major effector mediating early spontaneous abortion (less than day 8-10), CBA female mice mated by DBA/2 males were treated with either polyinosinic/cytidylic acid (poly I:C) to boost NK activity, or rabbit anti-asialo GM1 (RaASGM1) to decrease NK activity. The results of the NK assays of the spleens of treated mice confirmed that the reagents had the expected effect on NK activity and an inspection of the uteri indicated a significant increase in aborted embryos after poly I:C and a marked decrease in spontaneous abortions after RaASGM1 treatment. Therefore, spontaneous abortions may be mediated in part by the cytotoxic activity of unregulated NK cells.
与流产胎儿相关的效应细胞似乎既有胸腺来源的（T）细胞，也有自然杀伤（NK）细胞。为了验证NK细胞是介导早期自然流产（小于第8 - 10天）的主要效应细胞这一假设，将CBA雌性小鼠与DBA/2雄性小鼠交配，然后用聚肌苷酸/胞苷酸（poly I:C）处理以增强NK活性，或用兔抗去唾液酸GM1（RaASGM1）处理以降低NK活性。对处理后小鼠脾脏进行NK检测的结果证实，这些试剂对NK活性有预期的影响，对子宫的检查表明，poly I:C处理后流产胚胎显著增加，而RaASGM1处理后自然流产明显减少。因此，自然流产可能部分是由不受调控的NK细胞的细胞毒性活性介导的。
