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1
Natural killer (NK) cells and graft-versus-host disease (GVHD): no correlation between the NK cell levels and GVHD in the murine P----F1 model.自然杀伤（NK）细胞与移植物抗宿主病（GVHD）：在小鼠P----F1模型中，NK细胞水平与GVHD之间无相关性。
Immunology. 1985 Jan;54(1):121-6.
2
The effects of polyinosinic:polycytidylic acid (pI:C) on the graft-vs-host (GVH) reaction. II. Increased NK-mediated rejection on C57BL/6 lymphocytes by (C57BL/6 X A)F1 mice.聚肌苷酸:聚胞苷酸（pI:C）对移植物抗宿主（GVH）反应的影响。II. （C57BL/6×A）F1小鼠增强对C57BL/6淋巴细胞的自然杀伤细胞介导的排斥反应
J Immunol. 1986 Dec 1;137(11):3420-7.
3
Depletion of asialo-GM1+ cells from the F1 recipient mice prior to irradiation and transfusion of parental spleen cells prevents mortality to acute graft-versus-host disease and induction of anti-host specific cytotoxic T cells.在对F1代受体小鼠进行照射和输注亲代脾细胞之前，去除其去唾液酸GM1+细胞可预防急性移植物抗宿主病导致的死亡，并阻止抗宿主特异性细胞毒性T细胞的诱导。
Clin Exp Immunol. 1987 Sep;69(3):652-9.
4
Prevention of lethal, minor-determinate graft-host disease in mice by the in vivo administration of anti-asialo GM1.通过体内给予抗唾液酸GM1预防小鼠致死性、微小决定性移植物抗宿主病。
J Immunol. 1983 Nov;131(5):2101-3.
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Reduction of acute graft-versus-host disease-related mortality and cytotoxic T lymphocyte induction after pretreatment of the recipient with anti-asialo GM1 antibody in the murine P-to-F1 model.在小鼠P-to-F1模型中，用抗去唾液酸GM1抗体预处理受体后，降低急性移植物抗宿主病相关死亡率并诱导细胞毒性T淋巴细胞
Transplant Proc. 1987 Feb;19(1 Pt 3):2690-1.
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A subset of asialo GM1+ cells play a protective role in the occurrence of graft-versus-host disease in mice.去唾液酸GM1+细胞亚群在小鼠移植物抗宿主病的发生中起保护作用。
J Immunol. 1991 Jun 15;146(12):4065-70.
8
Augmentation of the antimetastatic effect of anticoagulant drugs by immunostimulation in mice.通过免疫刺激增强抗凝药物在小鼠体内的抗转移作用。
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Experimental studies of immunologically mediated enteropathy. II. Role of natural killer cells in the intestinal phase of murine graft-versus-host reaction.免疫介导性肠病的实验研究。II. 自然杀伤细胞在小鼠移植物抗宿主反应肠道阶段中的作用。
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10
The effect of human IL-2-activated natural killer and T cells on graft-versus-host disease and graft-versus-leukemia in SCID mice bearing human leukemic cells.人白细胞介素-2激活的自然杀伤细胞和T细胞对携带人白血病细胞的重症联合免疫缺陷小鼠移植物抗宿主病和移植物抗白血病的影响。
Transplantation. 1995 Oct 27;60(8):821-7.

引用本文的文献

1
Natural Killer Cells in Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation.异基因造血细胞移植后移植物抗宿主病中的自然杀伤细胞
Front Immunol. 2017 Apr 25;8:465. doi: 10.3389/fimmu.2017.00465. eCollection 2017.
2
Depletion of asialo-GM1+ cells from the F1 recipient mice prior to irradiation and transfusion of parental spleen cells prevents mortality to acute graft-versus-host disease and induction of anti-host specific cytotoxic T cells.在对F1代受体小鼠进行照射和输注亲代脾细胞之前，去除其去唾液酸GM1+细胞可预防急性移植物抗宿主病导致的死亡，并阻止抗宿主特异性细胞毒性T细胞的诱导。
Clin Exp Immunol. 1987 Sep;69(3):652-9.
3
Studies of intestinal lymphoid tissue. XV. Histopathologic features suggestive of cell-mediated reactivity in jejunal mucosae of patients with dermatitis herpetiformis.肠道淋巴组织研究。十五。疱疹样皮炎患者空肠黏膜中提示细胞介导反应性的组织病理学特征。
Virchows Arch A Pathol Anat Histopathol. 1989;416(2):125-32. doi: 10.1007/BF01606317.

本文引用的文献

1
Graft versus host reactions. Their natural history, and applicability as tools of research.移植物抗宿主反应。其自然史及其作为研究工具的适用性。
Prog Allergy. 1962;6:349-467.
2
In vivo effects of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice.抗去唾液酸GM1的体内效应。I. 裸鼠自然杀伤细胞活性降低及移植瘤生长增强
J Immunol. 1981 Jul;127(1):34-8.
3
Natural killer activity by spleen, lymph node, and thymus cells during the graft-versus-host reaction.移植物抗宿主反应期间脾脏、淋巴结和胸腺细胞的自然杀伤活性。
Transplantation. 1982 Sep;34(3):144-6. doi: 10.1097/00007890-198209000-00006.
4
Display of the neutral glycolipid ganglio-n-tetraosylceramide (asialo GM1) on cells of the natural killer and T lineages.天然杀伤细胞和T细胞谱系细胞上中性糖脂神经节苷脂-n-四糖神经酰胺（脱唾液酸GM1）的展示。
Transplantation. 1982 Feb;33(2):118-22. doi: 10.1097/00007890-198202000-00003.
5
A glycolipid on the surface of mouse natural killer cells.小鼠自然杀伤细胞表面的一种糖脂。
Eur J Immunol. 1980 Mar;10(3):175-80. doi: 10.1002/eji.1830100304.
6
Natural killer activity in (C57BL/6 X DBA/2)F1 hybrids undergoing acute and chronic graft-vs.-host reaction.在经历急性和慢性移植物抗宿主反应的（C57BL/6×DBA/2）F1杂交种中的自然杀伤活性。
Eur J Immunol. 1983 Nov;13(11):912-9. doi: 10.1002/eji.1830131110.
7
Prevention of lethal, minor-determinate graft-host disease in mice by the in vivo administration of anti-asialo GM1.通过体内给予抗唾液酸GM1预防小鼠致死性、微小决定性移植物抗宿主病。
J Immunol. 1983 Nov;131(5):2101-3.
8
Elimination of allogeneic lymphocytes by mice.小鼠对同种异体淋巴细胞的清除。
Immunol Rev. 1983;73:5-34. doi: 10.1111/j.1600-065x.1983.tb01076.x.
9
Allogeneic bone-marrow transplantation.异基因骨髓移植
Immunol Rev. 1983;71:77-102. doi: 10.1111/j.1600-065x.1983.tb01069.x.
10
Possibility of graft-vs-leukemia determinants independent of the major histocompatibility complex in allogeneic marrow transplantation.异基因骨髓移植中不依赖主要组织相容性复合体的移植物抗白血病决定因素的可能性。
Transplantation. 1983 Apr;35(4):378-85. doi: 10.1097/00007890-198304000-00023.

自然杀伤（NK）细胞与移植物抗宿主病（GVHD）：在小鼠P----F1模型中，NK细胞水平与GVHD之间无相关性。

Natural killer (NK) cells and graft-versus-host disease (GVHD): no correlation between the NK cell levels and GVHD in the murine P----F1 model.

作者信息

Varkila K, Hurme M

出版信息

Immunology. 1985 Jan;54(1):121-6.

PMID:3972429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454846/
Abstract

Graft-versus-host disease (GVHD) was induced in (CBA X C57BL/6) F1 mice by i.v. injection of 50 X 10(6) parental spleen cells. The GVHD induced an enhanced NK (anti-YAC-1) cytotoxicity during the first 2 weeks after the spleen cell transfusion. This cytotoxic activity was shown to be mediated by asialo GM1-positive, partially Thy-1-positive and nylon-wool (NW) non-adherent cells, thus being classical NK cells. Depletion of NK-cell activity from donor and/or recipient mice with anti-asialo GM1 antibody prior to the spleen cell transfer did not prevent the GVHD as judged by the splenomegaly assay. Also, when NK activity was potentiated with polyinosinic-polycytidylic acid (pIC), no effect on the GVHD was seen. These data suggest that NK cells are not crucial for the development of GVHD in this model.

摘要

通过静脉注射50×10⁶个亲代脾细胞，在（CBA×C57BL/6）F1小鼠中诱导移植物抗宿主病（GVHD）。在脾细胞输注后的前2周内，GVHD诱导了增强的NK（抗YAC-1）细胞毒性。这种细胞毒性活性被证明是由去唾液酸GM1阳性、部分Thy-1阳性和尼龙毛（NW）非黏附细胞介导的，因此是经典的NK细胞。在脾细胞转移前，用抗去唾液酸GM1抗体耗尽供体和/或受体小鼠的NK细胞活性，通过脾肿大测定判断并不能预防GVHD。此外，当用聚肌苷酸-聚胞苷酸（pIC）增强NK活性时，未观察到对GVHD有影响。这些数据表明，在该模型中，NK细胞对于GVHD的发展并非至关重要。