O'Shaughnessy R, Reiss R, Scott-Tibbs G, McSweeney E
J Reprod Med. 1987 Jul;32(7):504-8.
Catecholamines accumulate in platelets, and platelet catecholamine concentrations may give a more stable index of sympathoadrenal activity than do random plasma values. We measured norepinephrine in plasma and platelets from normal, nonpregnant women and from normal and preeclamptic pregnant women with a radioenzymatic assay. Plasma and platelet norepinephrine was not markedly different in normal, pregnant women during the third trimester, intrapartum or postpartum when compared with those levels in nonpregnant women. Platelet norepinephrine was significantly elevated in women with mild preeclampsia, but plasma norepinephrine was not. A linear relationship existed between platelet count and platelet norepinephrine concentrations in women with preeclampsia. These findings are compatible with the hypothesis of increased sympathoadrenal activity in women with mild preeclampsia and normal platelet counts. The lower platelet norepinephrine in thrombocytopenic patients suggests that platelet activation and degranulation have occurred and indicate that platelet catecholamine concentration does not provide a stable index of sympathoadrenal activity when platelets are being consumed.
儿茶酚胺在血小板中蓄积，与随机血浆值相比，血小板儿茶酚胺浓度可能是反映交感肾上腺活动更稳定的指标。我们采用放射酶法测定了正常未孕女性、正常孕妇及先兆子痫孕妇血浆和血小板中的去甲肾上腺素。与未孕女性相比，正常孕妇在妊娠晚期、分娩期及产后血浆和血小板中的去甲肾上腺素水平无明显差异。轻度先兆子痫女性的血小板去甲肾上腺素水平显著升高，但血浆去甲肾上腺素水平未升高。先兆子痫女性的血小板计数与血小板去甲肾上腺素浓度之间存在线性关系。这些发现与轻度先兆子痫且血小板计数正常的女性交感肾上腺活动增强的假说相符。血小板减少患者的血小板去甲肾上腺素水平较低，提示血小板已发生激活和脱颗粒，表明当血小板被消耗时，血小板儿茶酚胺浓度不能提供反映交感肾上腺活动的稳定指标。
